Searchable abstracts of presentations at key conferences in endocrinology

ea0081p26 | Adrenal and Cardiovascular Endocrinology | ECE2022

Prevalence of NCAH, defined by 17-hyroxyprogesterone levels after ACTH-stimulation test, in a population with adrenal incidentaloma

Sahlander Fredrik , Bensing Sophie , Falhammar Henrik

Background: Nonclassic congenital adrenal hyperplasia (NCAH) is a condition associated with adrenal masses and suggested by current European guidelines to be considered in case of bilateral adrenal lesions. NCAH is caused by different mutations in the CYP21A2 gene coding for the 21-hydoxylase enzyme in the glucocorticoid synthesis leading to mild cortisol deficiency and elevated androgen and steroid precursor levels. 17-hydroxyprogesterone (17OHP) is the most importan...

ea0063p858 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Prevalence of autonomous cortisol secretion as defined in ESE guidelines in a Swedish cohort of patients diagnosed with adrenal incidentaloma: A prospective study in regional Sweden

Sahlander Fredrik , Bensing Sophie , Falhammar Henrik

Background: Resource-saving and medically safe investigations of adrenal incidentaloma (AI) is one of the challenges in modern endocrinology. The absolutely majority of AIs are benign and hormonally inactive. Mild hypercortisolemia is the most common finding in hormonally active AI and is often referred to as subclinical Cushing syndrome (SCS). SCS is associated with increased risk of type 2 diabetes, poorly regulated hypertension, osteoporosis and cardiovascular disease. Ther...

ea0070aep53 | Adrenal and Cardiovascular Endocrinology | ECE2020

Trends in the incidence of adrenal incidentaloma diagnosed by CT abdomen in 2002 and 2015: Preliminary data from a retrospective study in regional sweden

Sahlander Fredrik , Bensing Sophie , Falhammar Henrik

Background: Adrenal incidentalomas (AI) are common and reported at frequencies of 2-10% at CT-scans of the abdomen. It is established that the number of diagnosed and investigated cases of AI have increased over the last decades. This increase is closely related to the development of modern radiology. General access of CT scanners with higher performance have led to an improved capacity and consequently more performed investigations. Other contributing factors are improved ima...

ea0056oc10.1 | Cardiovascular aspects of endocrine diseases | ECE2018

Glucocorticoid replacement-doses and cardiovascular events in autoimmune Addison’s disease – a population based retrospective cohort study

Skov Jakob , Sundstrom Anders , Ludvigsson Jonas , Kampe Olle , Bensing Sophie

Objective: Mortality in autoimmune Addison’s disease (AAD) is increased twofold compared to matched populations. Cardiovascular disease (CVD) is the most common cause of death, but little is known of cardiovascular morbidity. Inadequate glucocorticoid replacement has been implicated in the increased risk of CVD, but evidence is lacking. The objective of this study was to examine cardiovascular morbidity and mortality in AAD, and to investigate the effects of glucocorticoi...

ea0056p65 | Adrenal cortex (to include Cushing's) | ECE2018

A systematic survey of low S-cortisol levels at the department of clinical chemistry: indications for testing and frequency of undiagnosed adrenal insufficiency

AEkerman Anna-Karin , Bartuseviciene Inga , Hoybye Charlotte , Bensing Sophie

A systematic survey of low S-cortisol levels at the department of clinical chemistry: indications for testing and frequency of undiagnosed adrenal insufficiency.Background: S-cortisol is frequently analyzed at clinical chemistry departments. Low levels of S-cortisol needs to be promptly acted on if the cause is undiagnosed adrenal insufficiency (AI). The causes of S-cortisol testing are however multiple and low levels are necessarily not alarming if foun...

ea0081p519 | Adrenal and Cardiovascular Endocrinology | ECE2022

Brain Structure in a cohort of young adult patients with Autoimmune Addison’s Disease

van't Westeinde Annelies , Padilla Nelly , Strom Sara , Kampe Olle , Bensing Sophie , Lajic Svetlana

Background: Both cortisol and other adrenal hormones are well known to affect brain structure and function throughout development. Due to destruction of the adrenal cortex, patients with Autoimmune Addison’s disease (AAD) lack production of adrenal hormones and therefore receive lifelong replacement of cortisol and aldosterone, and, for some female patients dehydroepiandrosterone (DHEA). However, replicating the natural rhythm of secretion is difficult, and patients are o...

ea0032p930 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

A rare case of pituitary infarction in an 11-year-old pre-pubertal girl with pituitary autoantibodies to piccolo

Crock Patricia , Maltby Vicki , Smith Casey J A , Bensing Sophie , Ludecke Dieter K , Kampe Olle

Introduction: Generously supported by IPSEN)-->Pituitary infarction is rare in the paediatric age. In adolescents and adults it is often secondary to haemorrhage into an underlying lesion such as pituitary adenoma or cyst. Lymphocytic hypophysitis is rare in children and usually peri-tumoral due to germinoma, craniopharyngioma or Rathke’s cyst and often associated with hypopituitarism and diabetes insipidus.<p class="abstext...

ea0031p327 | Steroids | SFEBES2013

The role of anti-ACTH1–24 antibodies in synacthen-related adverse events

Gan Earn H , MacArthur Katie , Mitchell Anna L , Crock Patricia , Bensing Sophie , Pearce Simon H S

Background: Immune responses to self-peptides should not generally occur. However, four of 12 autoimmune Addison’s disease (AAD) patients developed adverse reactions immediately after synacthen injections, following repeated subcutaneous synacthen injections during a clinical trial (RoSA study). We wondered if these adverse effects were due to the production of anti-synacthen (ACTH1–24) antibodies.Methods: We evaluated the presence o...

ea0014p553 | (1) | ECE2007

Growing incidence of idiopathic isolated secondary adrenal insufficiency.

Kasperlik-Zaluska Anna , Czarnocka Barbara , Papierska Lucyna , Bensing Sophie , Hulting Anna , Crock Patricia

Objective: The origin of idiopathic isolated secondary adrenal insufficiency (IISAI) is uncertain, however autoimmunity seems to be the most probable cause. Within last eight years the initial number of about 100 such cases, increased in our registry by 250%. We searched for features of autoimmune diseases in our group of patients to prove autoimmune etiology in a majority of these patients.Materials and methods: The material consisted of 260 patients wi...

ea0070aep1096 | Hot topics (including COVID-19) | ECE2020

Limited genetic overlap between Hashimoto´s thyroiditis and Graves´ disease in Swedish twins: A population-based study

Skov Jakob , Calissendorff Jan , Eriksson Daniel , Ludvigsson Jonas , Magnusson Patrik , Kämpe Olle , Bensing Sophie , Kuja-Halkola Ralf

Background: Hashimoto´s thyroiditis (HT) and Graves´ disease (GD) are known co-aggregate in families, but the magnitude and nature of a shared etiology is unknown. The aim of this study was to estimate the shared genetic influence on these diseases. In addition, we sought to examine if the heritability of HT and GD differs between men and women.Methods: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swe...