Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep285 | Calcium and Vitamin D metabolism | ECE2015

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

Deledda Cristiana , Fibbi Benedetta , Giuliani Corinna , Benvenuti Susanna , Luciani Paola , Mazzanti Benedetta , Saccardi Riccardo , Peri Alessandro

Hyponatraemia represents an independent risk factor for osteoporosis and fractures, affecting both bone density and quality. A direct stimulation of osteoclastogenesis and bone resorption in the presence of reduced extracellular sodium concentrations ([Na+]) has been shown, but, to date, the effects of reduced [Na+] on osteoblasts have not been elucidated. This study investigated the effects of a chronic reduction of extracellular [Na+], independently of osmotic stress, on hum...

ea0032p623 | Growth hormome IGF axis – basic | ECE2013

Low extracellular sodium causes neuronal distress independently of reduced osmolality in an experimental model of chronic hyponatremia

Deledda Cristiana , Luciani Paola , Benvenuti Susanna , Modi Giulia , Bossio Alessandro , Giuliani Corinna , Fibbi Benedetta , Peri Alessandro

Introduction: There is evidence that chronic mild hyponatremia (serum (Na+) 130–135 mmol/l) may have clinical consequences, such as fracture occurrence and neurological symptoms including unsteadiness, falls and attention deficits. These have been traditionally associated to water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts negative effects on human neuronal...

ea0016oc1.7 | Neuroendocrinology and pituitary | ECE2008

Intermittent high glucose concentrations reduce neuronal precursor proliferation by altering the IGF system: the involvement of the neuroprotective factor seladin-1

Giannini Stefano , Pezzatini Anna , Luciani Paola , Manuelli Cinzia , Benvenuti Susanna , Cellai Ilaria , Deledda Cristiana , Vannelli Gabriella Barbara , Rotella Carlo Maria , Serio Mario , Peri Alessandro

The exposure of cells to high glucose concentrations is considered a determinant of diabetic neuropathy. Conversely, members of the Insulin-like Growth Factor (IGF) system are well known neurotrophic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF-I and IGF Binding Proteins (IGFBPs) in human neuroblast long-term cell cultures (FNC). We first demonstrated that FNC express the IGF-I receptor, and express and release in t...

ea0014p530 | (1) | ECE2007

The expression of the neuroprotective factor seladin-1 is up-regulated by thyroid hormones in human neuronal precursor cells, but not in mature neurons

Benvenuti Susanna , Luciani Paola , Cellai Ilaria , Deledda Cristiana , Saccardi Riccardo , Urbani Serena , Vannelli Gabriella B , Francini Fabio , Squecco Roberta , Serio Mario , Pinchera Aldo , Peri Alessandro

Thyroid hormones (TH) play a fundamental role during brain development by modulating the expression of different genes involved in neuronal differentiation, proliferation, migration, myelinization, and synapse formation. Seladin-1 (for SELective Alzheimer’s Disease INdicator-1) is a recently identified anti-apoptotic gene, which has been found to be down-regulated in brain regions affected by Alzheimer’s disease (AD). We hypothesized that seladin-1 might be a ...

ea0020htb2 | Hot topics: Basic | ECE2009

Characterization of human adult stem cell populations isolated from subcutaneous and visceral adipose tissue

Baglioni Silvana , Francalanci Michela , Squecco Roberta , Lombardi Adriana , Cantini Giulia , Angeli Roberta , Gelmini Stefania , Guasti Daniele , Benvenuti Susanna , Annunziato Francesco , Bani Daniele , Liotta Francesco , Francini Fabio , Perigli Giuliano , Serio Mario , Luconi Michaela

White adipose tissue acts as an endocrine organ that secretes a variety of adipokines and coordinates a number of biological processes such as energy homeostasis, neuroendocrine and immune functions. Recent studies demonstrated that abundant adipose tissue depots (particularly visceral adipose tissue), by producing inflammatory cytokines, contribute to chronic low-grade inflammation processes which may underlie the pathogenesis of metabolic disorders such as obesity, atheroscl...