Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp142 | Female Reproduction | ECE2017

Steroid receptors involvement in enamel hypomineralization resulting from exposure to low-dose DEHP and bisphenol A

Ai Thu Bui , Houari Sophia , Loiodice Sophia , Jedeon Katia , Berdal Ariane , Babajko Sylvie

The environment has become increasingly contaminated by various pollutants including endocrine disrupting chemicals (EDCs). This has led to an increase in the incidence and gravity of known pathologies and the emergence of new ones, including dental pathologies as the Molar Incisor Hypomineralization (MIH). Among the thousands of EDCs, bisphenol A (BPA) and phthalates (DEHP) are widely used by the plastic industry and responsible to frequent contaminations. We previously showe...

ea0041oc10.1 | Reproduction & Endocrine Disruption | ECE2016

Systemic enamel pathologies may be due to anti-androgenic effects of some endocrine disruptors

Jedeon Katia , Loiodice Sophia , Houari Sophia , Lenormand Manon , Berdal Ariane , Babajko Sylvie

There has been increasing concerns over the last 20 years about the potential adverse effects of endocrine disruptors (EDs). Anecdotally, molar incisor hypomineralization (MIH), a recently described enamel pathology, now affecting 15–18% of 6–9 years old children, is increasing concurrently with ED related pathologies. Our previous data show that bisphenol A (BPA) and vinclozolin, two anti-androgenic EDs, impact amelogenesis and enamel mineralization preferentially i...

ea0037gp.08.06 | Reproduction: Male and endocrine disruptors | ECE2015

Bisphenol A affects amelogenesis by modulating enamel key genes expression

Jedeon Katia , Houari Sophia , Mcalpin Blake , Loiodice Sophia , Berdal Ariane , Babajko Sylvie

Bisphenol A (BPA) is a widespread endocrine disruptor commonly used by plastic industries. More than 95% of the world population contains BPA (ng/ml) in biological fluids raising the question of its activity and potential adverse effects. Anecdotally, molar incisor hypomineralisation (MIH), an enamel pathology affecting 15–18% of children, is increasing concurrently with ED related pathologies. Our previous data show that BPA impacts amelogenesis and generate similar enam...

ea0035p509 | Endocrine disruptors | ECE2014

Estrogen and bisphenol A affect enamel formation by different signaling pathways

Jedeon Katia , Loiodice Sophia , Marciano Clemence , Lavier Marie-Chantal Canivenc , Berdal Ariane , Babajko Sylvie

Bisphenol A (BPA) is a widespread endocrine disrupting chemical strongly suspected to have adverse health effects. Numerous tissues and cells are affected by BPA, and we showed recently that BPA targets include ameloblasts and enamel. We therefore investigated the effects of BPA on ameloblasts and the possible involvement of the estrogen signaling pathway. Rats were exposed daily to low-dose BPA from the conception to 30 days after birth (30 D). Seventy-five percent of 30 D ra...

ea0056p615 | Endocrine Disruptors | ECE2018

Disruption of amelogenesis by Adult Exposure to Di(2-ethylhexyl) Phthalate in Mice

Babajko Sylvie , Bui Ai Thu , Houari Sophia , Houari Sophia , Berdal Ariane

MIH (Molar Incisor Hypomineralyzation) is a recently described enamel pathology that affects now 15 to 18% of children worldwide. Its prevalence increased similarly to other pathologies associated to exposure to Endocrine Disrupting Chemicals (EDCs). In addition, MIH affects selectively permanent first molars and incisors, the first developing teeth during the perinatal period also the time window with the highest susceptibility to EDCs. Our previous published data showed the ...

ea0032oc2.6 | Bone & Calcium | ECE2013

Hypomineralized teeth as biomarkers of exposure to endocrine disruptors

Jedeon Katia , Molla De La Dure Muriel , Brookes Steven , Marciano Clemence , Canivenc-Lavier Marie-Chantal , Berdal Ariane , Babajko Sylvie

MIH for Molar Incisor Hypomineralization is a recently described pathology affecting around 18% of six year old children. Although a number of putative factors have been hypothesized, etiology of MIH remains unknown. The parallel increase of exposure to endocrine disruptors (EDs) and the prevalence of MIH led us to investigate a possible relationship between both events.Rats were orally exposed daily to low dose of bisphenol A (BPA), genistein, vinclozol...