Searchable abstracts of presentations at key conferences in endocrinology

ea0077pl6 | Society for Endocrinology European Medal Lecture | SFEBES2021

Rethinking critical illness-related corticosteroid insufficiency

Berghe Greet Van den

Critical illnesses are characterized by increased systemic cortisol availability, a vital part of the stress response. ‘Relative adrenal failure’ (later termed critical illness-related corticosteroid insufficiency or CIRCI) is a condition in which the systemic availability of cortisol is assumed to be insufficiently high to face the stress of the illness, and is most typically thought to occur in the acute phase of septic shock. Researchers suggested that CIRCI can b...

ea0097001 | Section | BES2023

Hydrocortisone treatment increases cholesterol availability in prolonged septic mice: effect on adrenal and muscle functioning

Bruyn Lauren De , Arno Teblick , Oudenhove Tim Van , Perre Sarah Vander , Inge Derese , Lies Pauwels , Sarah Derde , Berghe Greet Van den , Lies Langouche

Background: Sepsis is hallmarked by an immediate and sustained decrease in total-, HDL-, and LDL- cholesterol, associated with poor outcome and suggested to be a potential contributor to adrenal failure and muscle weakness in the critically ill. Although the underlying mechanisms are unclear, this sepsis-induced hypocholesterolemia has been postulated to be due to an increased conversion of cholesterol to cortisol. We hypothesized that hydrocortisone (HC) trea...