Endocrine Abstracts

Internal jugular vein thrombosis (IJVT) is generally related to central venous access devices (CVADs) because of endothelial trauma or inflammation. Other reported causes include neck surgery complication, malignancies, deep neck infections, intravenous drug abuse, ovarian hyperstimulation syndrome and hypercoagulable states.We report the case of a 47-year-old woman presenting with acute neck pain, local swelling and fever. Neck ultrasound with Doppler s...

Pituitary macroadenomas usually present with symptoms due to a local mass effect or to hormone abnormalities. Acromegaly is due an excessive GH production, usually caused by a slow-growing pituitary adenoma. Acromegaly is an insidious disease. An average delay of 7 years is reported between the time of symptoms onset and diagnosis. According to main symptoms, acromegaly is usually diagnosed by internists, ophthalmologists or rheumatologists. It may be suspected by pneumologist...

An 82-year-old woman with a history of breast carcinoma and hypertension underwent right laparoscopic adrenalectomy for a large mass (7×5 cm) of high density without contrast (>30 UH), non-secreting. Anatomapathological examination concluded to an adrenocortical adenoma without signs of malignancy: Weiss score of 2 and Ki67 <2%. Two years later, she developed polycythemia (Hb: 17.9 g/dl (N: 11.8–15.5); hematocrit: 53.5% (N: 35.3–46.1)) without involvemen...

Introduction: Neurofibromatosis type 1 (NF1) is one of the most frequent genetic dominant syndrom in men with a prevalence of 1 in 2600 to 3000 individuals worldwide. NIH NF1 diagnostic criteria are driven by the most frequent manifestations of the disease (café au lait macules (CAL), neurofibromas, freckling, optic glioma, Lisch nodules and osseus lesions). There are many clinical manifestations of NF1 (neurological, cardiovascular, gastrointestinal, endocrine and orthop...

Case report: A 81-year-old male patient suffering from a Gleason 9 pT3aN0M0R1 prostatic adenocarcinoma was treated with radical prostatectomy and adjuvant radiotherapy in 2014. He presented in outpatient clinic for lumbar pain in October 2018. A 18F-NaF PET/CT showed diffuse metastatic bone involvement. Laboratory results showed hypophosphatemia (0.52 mmol/L, N: 0.75–1.39), normal renal function, normocalcemia (2.35 mmol/L, N: 2.20–2.55), normal 25-OH vitamin D (36 μg/L, N: 30...

Introduction: Measurements of midnight salivary cortisol, 24-hour urinary free cortisol (UFC) and 1mg overnight Dexamethasone (DXM) suppression test (short DST) represent classical first line screening tests to diagnose Cushing syndrome. In women using combined Estrogen–Progestogen contraception, cortisol response during short DST is often decreased, leading to false positive (FP = morning plasma cortisol post-DST > 50 nmol/l).Purpose: The main ...

Background and aim: Insulin tolerance test (ITT) is the gold standard for the diagnosis of cortisol and growth hormone deficiencies in adults. Once hypoglycaemia (<40 mg/dl) is achieved, some medical centers give sugar to their patients (food, drink or glucose infusion), others do not and let the blood glucose rise spontaneously. Although critical hypoglycaemia results in discomfort and potential complications for the patients there is so far no recommendation on the subje...

Objectives: To systematically characterize autonomously functioning thyroid nodules (AFTN) by clinical, biological and imaging methods, cytology and histology when indicated.Design: Prospective, single-center study conducted from March 2018 until September 2021, in 901 consecutive patients with 67 AFTN evaluated.Methods: Enrolled patients underwent 99mTcO4 scintigraphy evaluation of thyroid function, ultrasound (US) usin...

Introduction: Neurofibromatosis type 1 (NF1) is one of the most frequent genetic dominant syndrom in men with a prevalence of 1 in 2600 to 3000 individuals worldwide. NIH NF1 diagnostic criteria are driven by the most frequent manifestations of the disease (‘café au lait’ macules (CAL), neurofibromas, freckling, optic glioma, Lisch nodules and bone lesions). There are many clinical manifestations of NF1 (neurological, cardiovascular, gastrointestinal, endocrine ...

Introduction: Primary adrenal lymphoma is rare, representing less than 1% of non-Hodgkin lymphomas.1 The clinical presentation is non-specific, symptoms of adrenal insufficiency may occur with bilateral lesions, and work up can be tricky.2Background: A 60-year-old man was admitted mid-January 2020 for acute left abdominal pain. He had no medical history and didn’t smoke or take any medication. He had no history of recent trauma...