Searchable abstracts of presentations at key conferences in endocrinology

ea0022p404 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Ectopic insulin secretion from distant metastasis or ectopic metaplasia after total pancreatectomy for ACTH-secreting endocrine pancreatic tumor revealing a Von Hippel Lindau disease

Vantyghem Marie-Christine , Wild Damian , Neraud Barbara , Nghi-Beron Amandine , Raverdy Violeta , Steinling Marc , Wemeau Jean-Louis , Pattou Francois

Von Hippel Lindau disease (VHL) induces tumors of kidneys, central nervous system, pancreas and paragangliomas We report one case where ectopic Cushing syndrome revealed VHL. A 19-year old was referred for hirsutism and spaniomenorrhea revealing an ACTH-dependent Cushing syndrome. Mineralocorticoids, calcium metabolism, chromogranine A, calcitonine, pancreatic hormones and urinary 5-HIA were normal. Blood nor- and metanephrine were 5.12 μg/l (n<5) and 0.92 &#95...

ea0022p790 | Thyroid | ECE2010

Diagnosing a cribriform papillary thyroid cancer in a patient with familial adenomatous polyposis

Christine Do Cao , Hanan El Ouahabi , Amandine Berdelou , Emmanuelle Leuteurtre , Bruno Carnaille , Amandine Beron , Louis Wemeau Jean

Papillary thyroid carcinoma (PTC) is the most common malignancy originating from the thyroid gland. Although occurring predominantly as a sporadic disease, it may be associated with rare inherited circumstances such as familial adenomatous polyposis (FAP) FAP is an autosomal dominantly inherited cancer predisposition syndrome characterized by the progressive development of colorectal carcinoma. Most of available data report accompanying thyroid carcinoma in no more than 1&#150...

ea0070ep12 | Adrenal and Cardiovascular Endocrinology | ECE2020

Altered bone mass and microarchitecture in catecholamine-secreting malignant paraganglioma

Jannin Arnaud , Beron Amandine , Vieillard Marie-Hélène , Vantyghem Marie-Christine , Chapurlat Roland , Do Cao Christine , Espiard Stephanie

Introduction: Pheochromocytoma and most abdominal paraganglioma (PPGL) can secrete catecholamines. In vitro and in vivo, catecholamines modulate bone remodeling by stimulating bone resorption. In patients with PPGL, four studies have previously demonstrated an increase of biological markers of bone resorption, a decreased of bone density and a higher prevalence of vertebral fractures. We report two patients with malignant abdominal secreting paraganglioma pre...

ea0098t5 | Trials In Progress | NANETS2023

Phase 3 LEVEL trial of 177Lu-edotreotide vs everolimus in patients with advanced neuroendocrine tumors of lung or thymic origin (GETNE-T2217)

Capdevila Jaume , Fazio Nicola , Alvarez Rosa , Ansquer Catherine , Baldari Sergio , Baudin Eric , Benavent Marta , Benini Lavinia , Beron Amandine , Berruti Alfredo , Cingarlini Sara , del Olmo-Garcia Maribel , Deshayes Emmanuel , Garcia-Alvarez Alejandro , Garcia-Carbonero Rocio , Haissaguerre Magalie , Hernando Jorge , Anido Herranz Urbano , Jimenez-Fonseca Paula , Lepage Come , Llana Belen , Molina-Cerrillo Javier , Panzuto Francesco , Pubul Virginia , Sansovini Maddalena , Tafuto Salvatore , Taieb David , Teule Alex , Versari Annibale , Villacampa Guillermo , Walter Thomas

Background: Everolimus is the only approved drug for patients with advanced bronchopulmonary neuroendocrine tumors (NET), and there is an urgent unmet need for alternative treatments. Retrospective data for peptide receptor radionuclide therapy (PRRT) have demonstrated promising activity in somatostatin receptor (SST)-positive lung NET. This study aims to investigate the clinical efficacy, safety, and patient-reported outcomes when 177Lu-edotreotide is used to treat...