Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep592 | Obesity and cardiovascular endocrinology | ECE2015

Relationship between thyroid hormone status and concomitant medication in hyperlipidaemic patients with statin induced adverse effects

Berta Eszter , Zsiros Noemi , Nagy Endre , Paragh Gyorgy , Bodor Miklos

Statins are effective treatment for the prevention of cardiovascular diseases and used extensively worldwide. However, adverse effects induced by statins are the major barrier of maximalising cardiovascular risk reduction. Hypothyroidism and administration of drugs metabolised on the same cytochrome P450 (CYPP450) pathways where statin biotransformation occurs represent a significant risk factor for statin induced adverse effects including myopathy. Simvastatin, atorvastatin a...

ea0063p719 | Pituitary and Neuroendocrinology 2 | ECE2019

Control of hyperglycemia in a young male patient with gigantism during transition: a case report

Berta Eszter , Lengyel Inez Mercedesz , Halmi Sandor , Puskas Istvan , Felszeghy Enikő , Balogh Zoltan , Nagy Endre V , Bodor Miklos

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...

ea0037gp.27.08 | Thyroid – hyperthyroidism and treatment | ECE2015

There is a detectable immune activity in the orbits of all patients diagnosed with Graves' disease regardless of later development of Graves' orbitopathy

Berta Eszter , Ujhelyi Bernadett , Szabados Lajos , Galuska Laszlo , Erdei Annamaria , Gazdag Annamaria , Halmi Sandor , Nagy Endre , Bodor Miklos

Graves’ orbitopathy (GO) is a common complication of Graves’ disease (GD) which is often responding poorly to therapy. GO may develop before or together with, or during the course of GD. In an individual patient, the development of GO cannot be predicted. We assumed that orbital autoimmune activity is predictable using orbital 99mTc-labelled diethylenetriamine pentaacetic acid (99mTc-DTPA) SPECT. We aimed to determine whether any orbital autoimmune activity can be id...

ea0070ep364 | Pituitary and Neuroendocrinology | ECE2020

Insulinoma localized by Ca-stimulation angiography: A case report

Halmi Sándor , Berta Eszter , Erdei Annamária , Lengyel Inez , Nagy Endre V. , Bodor Miklós

Introduction: Insulinoma is a rare tumor of the beta cells of the pancreas. The clinical manifestation is diverse with hypoglycemia and autonomic neurological symptoms. For diagnosis the Whipple’s triad needs to be present: signs of hypoglycemia, glucose level under 3 mmol/l and the cessation of symptoms after administration of iv. glucose. The fasting test confirms the diagnosis. The most commonly used imaging techniques that may localize the tumor are the abdominal ult...

ea0056p1095 | Thyroid (non-cancer) | ECE2018

Serum chemerin and other dyslipidemia markers in patients with autoimmune thyroiditis

Berta Eszter , Harangi Mariann , Varga Viktoria E , Lorincz Hajnalka , Seres Ildiko , Halmi Sandor , Nagy Endre V , Paragh Gyorgy , Bodor Miklos

Aim: Chemerin, a recently discovered adipokine produced by the adipose tissue and liver, along with other atherosclerosis markers, was associated lately with metabolic syndrome and acts as chemoattractant for immune cells may also regulate immune cell properties. Autoimmune Hashimoto’s thyroiditis even with sTSH levels corrected to be within the normal range values may be accompanied by dyslipidemia presenting increased total-C, TG, LDL-C, and Lp(a), all of which are pote...

ea0073aep410 | General Endocrinology | ECE2021

Successful treatment of nesidioblastosis during the time of pandemic: A case report

Sándor Halmi , Berta Eszter , Lengyel Inez , Toth Judit , Kanyari Zsolt , Hutkai David , Nagy V Endre , Bodor Miklos

IntroductionIn the background of persistent hyperinsulinemic hypoglycemia the insulinomas of the pancreatic beta cells may be present, but in some rare cases we fail to identify a well-defined lesion and the insulin hypersecretion is caused by nesidioblastosis, a diffuse proliferation of the pancreatic islet cells. However, the localization of the lesion is necessary for proper treatment, in certain cases finding the insulinoma is difficult and can only ...

ea0081ep400 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of chemerin and serum advanced glycation end products in patients with autoimmune thyroiditis

Bak-Csiha Sara , Halmi Sandor , Hutkai David , Molnar Istvan , Katko Monika , Lőrincz Hajnalka , Harangi Mariann , Paragh Gyorgy , Nagy Endre , Bodor Miklos , Eszter Berta

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...

ea0090p241 | Thyroid | ECE2023

Investigations on fibroblast growth factor 21 and lipid parameters in patients with Hashimoto thyroiditis

Bak-Csiha Sara , Hutkai David , Lőrincz Hajnalka , Harangi Mariann , Bodor Miklos , Katko Monika , Nagy Endre , Paragh Gyorgy , Eszter Berta

Background: Fibroblast growth factor 21 (FGF21) is a hormonal regulator of lipid and glucose metabolism exerting protection against atherosclerosis by multiple actions on the blood vessels, liver, and adipose tissues. Enhanced FGF21 production in diabetes and obesity reduces the level of LDL-C and triglycerides by suppression of hepatic SREBP-2. Hypothyroidism has also been shown to have unfavorable effects on atherogenesis and dyslipidemia. To date, the association of lipid p...

ea0092ps2-11-03 | Miscellaneous 2 | ETA2023

Evaluation of advanced end glycation products (AGES), their solube receptors (SRAGE) and the components of oxidative stress in patients with hashimoto’s thyroiditis on levothyroxine substitution

Csiha Sara , Molnar Istvan , Halmi Sandor , Hutkai David , Lorincz Hajnalka , Somodi Sandor , Katko Monika , Harangi Mariann , Paragh Gyorgy , Nagy Endre V. , Bodor Miklos , Berta Eszter

Background: Advanced glycation end products (AGEs) are heterogenous group of irreversible chemical moieties originated from non-enzymatic glycation and oxidation of proteins, nucleic acids, and lipids. The engagement of AGEs with their chief cellular receptor (RAGE) activates signaling pathways contributing to the progression of chronic diseases like autoimmune thyroiditis, type 2 diabetes mellitus and its complications. Soluble RAGE (sRAGE) prevents AGE-RAGE interaction in a ...

ea0073aep634 | Thyroid | ECE2021

Evaluation of fetuin-A levels in patients with autoimmune thyroiditis

Eszter Berta , Sándor Halmi , Inez Mercédesz Lengyel , Mónika Katkó , Harangi Mariann , V Nagy Endre , György Paragh , Miklós Bodor

BackgroundHypothyroidism due to autoimmune thyroiditis (AITD) leads to atherogenic lipid profile and therefore might increase the cardiovascular risk of patients. Fetuin-A is a hepatokine with a role in the regulation of mineralization, metabolism and the cardiovascular system. Fetuin-A levels are known increased in obesity-linked diseases. To date, the role of fetuin-A in autoimmune thyroiditis has not been thoroughly investigated.<p class="abstext"...