Searchable abstracts of presentations at key conferences in endocrinology

ea0015p221 | Pituitary | SFEBES2008

Gamma knife radiosurgery: a safe and effective treatment for acromegaly

Swords FM , Monson JP , Besser GM , Chew SL , Drake WM , Grossman AB , Plowman PN

We report the use of Gamma knife radiosurgery (GK) to 15 somatotroph adenomas. Eight patients had refractory acromegaly despite maximal conventional treatments: all had undergone conventional radiotherapy (CRT), mean interval between CRT and GK 15.6 years. Six had undergone surgery, two on more than one occasion. Five were receiving somatostatin analog therapy, one was receiving dopamine agonist therapy, one was on pegvisomant alone. All had radiologically defined disease, wel...

ea0019p266 | Pituitary | SFEBES2009

Fifteen years experience of repeated colonoscopic screening of patients with acromegaly shows a high incidence of new colonic neoplasia and allows for effective screening guidelines

Dworakowska D , Gueorguiev M , Kelly P , Grossman AB , Monson JP , Besser GM , Chew SL , Akker S , Drake WM , Fairclough PD , Jenkins PJ

Introduction: Patients with acromegaly have an increased risk of colorectal cancer and pre-malignant adenomatous polyps; however the frequency of colonoscopic screening remains unclear.Aims: To determine optimum frequency for repeated colonoscopy of acromegalic patients.Methods: Since 1992, 254 patients (mean age 56.6 years) at our centre have undergone at least one fibre-optic colonoscopic surveillance; 156, 60 and 15 patients hav...

ea0017p23 | (1) | BSPED2008

Prepubertal Cushing's disease: diagnosis and therapeutic outcome

Kumaran A , Chan LF , Martin L , Afshar F , Matson M , Plowman PN , Monsoon JP , Besser GM , Grossman AB , Savage MO , Storr HL

Cushing’s disease (CD) is very rare in prepubertal children, and remains a challenge to diagnose and manage. We review the diagnostic features and therapeutic outcome of prepubertal (defined as testicular volume <4 ml (M) and breast stage <2 (F)) CD patients treated in a single centre. Fifteen prepubertal patients (median age 9.4 years; range 5.8–13.7) fulfilled standard diagnostic criteria for CD and there was male preponderance (12 M (80%), median age 9.1 y...

ea0011p179 | Clinical practise and governance | ECE2006

Improvements for patients and nurses using 2.5 ml prefilled syringes as the vehicle solution for suspension of Sandostatin LAR® microspheres

Maher KT , Drake WM , Besser GM , Grossman AB , Chew SL , Jenkins PJ , Kalingag LA , Fode FK , O’Sullivan-Hawketts MT , Walker DM , Monson JP

The preparation of Sandostatin LAR® injections using a 2 ml ampoule of vehicle solution may be associated with some technical difficulties of administration, with adverse consequences for patients. The development of a 2.5 ml prefilled syringe may alleviate some of these problems. We have compared these two methods of Sandostatin LAR® administration in 17 patients with acromegaly and 5 patients with neuro-endocrine tumours, (6 drug naïve, 1...