Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep331 | Clinical case reports - Thyroid/Others | ECE2017

The rare cause of primary hyperparathyroidism: Parathyroid Carcinoma

Bestepe Nagihan , Ozdemir Didem , Polat Sefika Burcak , Evranos Berna , Ersoy Reyhan , Cakir Bekir

Introduction: Parathyroid carcinoma (PC) is a rare endocrine malignancy which accounts for 0.005% of all cancers and less than 1% of primary hyperparathyroidism cases. This uncommon tumor usually occurs during the fifth decade of life, with equal frequency in both sexes, and has an indolent but progressive course. It’s frequently symptomatic and patients may have high values of serum calcium and parathyroid hormone (PTH) with a palpable cervical mass. PC generally occurs ...

ea0049ep843 | Clinical case reports - Pituitary/Adrenal | ECE2017

Coexistence of acromegaly and rheumatoid arthritis: presentation of three cases

Ersoy Reyhan , Bestepe Nagihan , Faki Sevgul , Bilginer Cuneyt , Ozdemir Didem , Erten Sukran , Cakir Bekir

Introduction: Musculoskeletal system is widely affected in acromegalic patients which might cause difficulties in the diagnosis and treatment of inflammatory rheumatological diseases. Here, we report coexistent rheumatoid arthritis (RA) in three acromegalic patients presenting with continuing joint and back pain although acromegalic state was in remission.Case 1: A 64 years old female patient with acromegaly and macroadenoma had undergone transsphenoidal...

ea0049ep1152 | Female Reproduction | ECE2017

Does radioactive ıodine therapy affect fertility?

Evranos Ogmen Berna , Faki Sevgul , Burcak Polat Sefika , Bestepe Nagihan , Ersoy Reyhan , Cakir Bekir

Introduction: Thyroid carcinoma is common in young women. Radioactive iodine (RAI) therapy has been confirmed as a useful treatment in the management of differentiated thyroid carcinoma (DTC). For women with DTC, the effect of RAI therapy on gonadal and reproductive function is an important consideration. We aimed to evaluate effects of RAI therapy on ovarian function.Method: Women younger than 40 years old and diagnosed with thyroid cancer that required...

ea0041ep301 | Clinical case reports - Pituitary/Adrenal | ECE2016

Acromegaly in a male patient with Kleinfelter syndrome

Burcak Polat Sefika , Bestepe Nagihan , Topaloglu Oya , Bal Ercan , Ersoy Reyhan , Cakir Bekir

Introduction: Klinefelter syndrome is known as the set of symptoms that result from two or more X chromosomes in males. There is no known association of this syndrome with GH hypersecretion. The most remarkable symptom is gigantism and it can also be observed in androgen deficient states as such as the Klinefelter syndrome and some more genetic syndromes such as the Sotos syndrome, the Marfan syndrome, the homocystinuria, and the fragile X-syndrome. Herein we presente...

ea0041ep674 | Female Reproduction | ECE2016

Pregnancy by Treatment for Graves Disease in a Patient with Primary Ovarian Failure

Evranos Berna , Polat Sefika Burcak , Baser Husniye , Bestepe Nagihan , Cakir Bekir

Introduction: Premature ovarian failure (POF) is a disorder associated with female infertility, and it affects approximately 1% of women under the age of 40 year. It is considered a multifactorial, heterogeneous condition, for which the exact underlying cause remains unclear. Associations with autoimmune diseases, environmental factors and genetic causes have been described. Herein we presented a case with POF who regained fertility after the treatment of Graves disease.<p...

ea0037ep174 | Reproduction, endocrine disruptors and signalling | ECE2015

47,XYY syndrome and hypogonadotropic hypogonadism: is this coincidence or a diverse spectrum of the syndrome?

Dellal Fatma Dilek , Aydin Cevdet , Bestepe Nagihan , Ersoy Reyhan , Cakir Bekir

Introduction: 47,XYY syndrome is characterized by an extra copy of the Y chromosome in each cells of a male. It occurs in about 1/1000 of newborn boys and most males with this syndrome have normal sexual development and fertility. They tend to have tall stature and mild motor and language developmental problems. Testosterone levels are normal. Increased rate of criminal activity in XYY males was related to a lack of judgement and lower socioeconomic status due to a lower mean ...

ea0037ep1265 | Clinical Cases–Thyroid/Other | ECE2015

Diabetes mellitus in a patient with Leri–Weill dyschondrosteosis

Ozdemir Didem , Polat Sefika Burcak , Bestepe Nagihan , Ozbek Saliha , Ersoy Reyhan , Cakir Bekir

Introduction: Leri–Weill dyschondrosteosis (LWD) is a rare autosomal dominant dyschondrosteosis characterised by Madelung deformity and mesomelic dwarfism. Majority of cases are associated with haploinsufficiency of the short-stature homeobox-containing (SHOX) gene. Here we report a patient with LWD and diabetes mellitus (DM).Case report: A 31 years old man applied with polyuria and polydipsia. He did not have any chronic disease. In family history,...

ea0070aep138 | Bone and Calcium | ECE2020

A new and valuable predictor for the diagnosis of primary hyperparathyroidism: Ca/P Ratio

Bestepe Nagihan , cuhaci Neslihan , Polat Burcak , Ogmen Berna , Ersoy Reyhan , Cakir Bekir

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder that is characterized by hypercalcemia and elevated or normal levels of parathyroid hormone (PTH). Most PHPT cases are incidentally discovered when routine laboratory analysis reveals hypercalcemia. PHPT should be considered in any person with elevated serum calcium (Ca) levels and no clear evidence of malignancy. Serum phosphorus (P) is low due to the phosphaturic effects of PTH and mostly in the ...

ea0070ep349 | Pituitary and Neuroendocrinology | ECE2020

Intravenous dexamethasone suppression test in cushing syndrome diagnosis: Three cases

Ince Urcan , Aydin Cevdet , Yildirim Deryol Hilal , Bestepe Nagihan , Topaloglu Oya , Berker Dilek

Introduction: Dexamethasone Suppression Test (DST) is a useful approach in diagnosis and differential diagnosis of Cushing Syndrome (CS) despite its limitations. One of the major limitations is the difficulty to provide standard suppression dose depending on the variability of gastrointestinal absorption. One solution is for this testing serum Dexamethasone levels or test it with intravenous (iv) Dexamethasone In this case, we examined 3 patients to whom we applied intravenous...

ea0056p186 | Bone ' Osteoporosis | ECE2018

Teriparatide treatment in a patient with atypical femoral fractures associated with long-term bisphosphonate therapy

Bestepe Nagihan , Aydin Cevdet , Evranos Berna , Topaloglu Oya , Ersoy Reyhan , Cakir Bekir

Introduction: Bisphosphonates are the most commonly used drugs for the treatment of osteoporosis and have been shown to improve bone mineral density and reduce fractures. However, approximately a decade ago, atypical femoral shaft fractures were found to be a rare complication of bisphosphonate treatment. Atypical Femoral Fractures (AFF) represent fractures located between the lesser trochanter and the supracondylar flare of a femur. An increasing pool of evidence supports the...