Searchable abstracts of presentations at key conferences in endocrinology

ea0063p624 | Diabetes, Obesity and Metabolism 2 | ECE2019

Augmented Mitophagy and Inflammasome Activation with Metformin therapy in patients with T2DM

Bhansali Shipra , Bhansali Anil , Dhawan Veena

Background: Impaired mitophagy (mitochondrial autophagy) and NLRP3 inflammasome activation have been implicated in the etiopathogenesis of insulin resistance and T2DM. Metformin beside being an insulin-sensitizer, also induces autophagy. However, further research is warranted in elucidating its effect on mitophagy and NLRP3 activation in patients with T2DM.Methods: 45 drug-naïve, newly diagnosed T2DM patients, with HbA1C 53–75 mmol/m...

ea0006p36 | Endocrine tumours and neoplasia | SFE2003

Macroprolactinomas in men: long-term efficacy of bromocriptine treatment

Chattopadhyay A , Bhansali A , Dash R

Gender-specific differences in tumor size at clinical presentation and possible differences in tumor biology make it important to determine treatment outcomes of male patients with bromocriptine [BRC]. We retrospectively analysed treatment response to bromocriptine in 29 male patients with macroprolactinoma (15) and giant macroprolactinoma (14). The duration of treatment was 6-96 months (mean 22.7). Clinical features at presentation included headache (21, 72.4%), visual field ...

ea0063p489 | Calcium and Bone 2 | ECE2019

Pregnancy, pancreatitis and hypoglycemia: Difficult management options in a case with MEN-1

Aggarwal Anshita , Bhadada Sanjay , Bhansali Anil

Abstract: A 32-year-old lady presented to us at 6 months of gestation with parathyroid hormone (PTH) -dependent hypercalcemia mediated pancreatitis and endogenous insulin dependent hypoglycemia, owing to parathyroid adenoma and possibly insulinoma, respectively. The parathyroid adenoma was localized on the MRI of the neck; however, no imaging for the insulinoma could be done due to the gravid state. Due to the simultaneous occurrence of tumors in two endocrine glands, namely, ...

ea0037oc4.5 | Diabetes | ECE2015

Efficacy of mesenchymal stem cells transplantation on glycaemic profile in streptozotocin induced diabetic Wistar rat

Bhansali Shobhit , Kumar Vinod , Saikia Uma Nahar , Jha Vivekanand , Bhansali Anil , Dutaa Pinaki

Introduction: Bone marrow is an abundant source of adult stem cells that can differentiate into various cell types. Administration of mesenchymal stem cells (MSCs) in irradiated diabetic rat model has transiently shown to decrease blood glucose level. This study examines the effect of high dose and multiple injections of MSCs on glycaemic profile, their localisation and regeneration of islet in diabetic Wistar rat.Methods: The study was carried out in ma...

ea0037gp.12.04 | Diabetes and obesity – Translational diabetes | ECE2015

Efficacy of autologous bone marrow derived mesenchymal stem cell transplantation in T2DM: a randomised placebo-controlled study

Bhansali Shobhit , Kumar Vinod , Jha Vivekanand , Marwah Neelam , Khandelwal N , Bhansali Anil , Dutta Pinaki

Introduction: There is a growing interest in cell-based therapies in T2DM as β-cell failure is progressive and inexorable. This study evaluates the efficacy of autologous bone marrow-derived mesenchymal stem cell transplantation (ABM-MSCT) in T2DM.Methods: This prospective, randomised, single-blinded placebo-controlled study enrolled 20 patients with triple oral hypoglycaemic drug failure and requiring insulin ≥0.4 Units/kg per day for achievi...

ea0025p127 | Diabetes, metabolism and cardiovascular | SFEBES2011

Utility of glycated haemoglobin in diagnosing prediabetes in Asian Indians- A Community Survey: Chandigarh Urban Diabetes Study (CUDS) group

Padala Ravikumar , Bhansali Anil , Walia Rama , Ravikiran M , Sunder G , Bhansali Shobhit , Bhadada Sanjay , Dutta Pinaki

Aim: To determine the HbA1c cut-offs for diagnosis of prediabetes based on isolated IFG, isolated IGT and both IFG and IGT.Methods: Cross-sectional randomized population survey involving 2368 adults, aged ≥20 years. HbA1c was measured on a Bio-Rad 10 system in 1972 subjects.Results: Among 1972 studied subjects, 329 were detected to have prediabetes based on isolated IFG in 125 (6.3%), isolated IGT in 141 (7.1%) and both in 63...

ea0025p2 | Bone | SFEBES2011

Influence of age and gender on expression of primary hyperparathyroidism

Shah Viral , Bhadada Sanjay , Bhansali Anil , Dutta Pinaki , Behara A

Background: The geographical difference in presentation of primary hyperparathyroidism (PHPT) is well known however, there is spare literature on influence of age and gender on presentation of PHPT.Objective: To study the effect of age and gender on clinical and biochemical presentation of PHPT.Method: This is a retrospective analysis of 184 histopathologically proven PHPT patients between March 1990 and March 2010 from a single ce...

ea0008p49 | Endocrine Tumours and Neoplasia | SFE2004

HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA

Dutta PD , Bhansali AB , Dradotra B , Singh P

Case report;A 42-year-old male presented with headache, coarserning of facial features, enlargement of body parts of 2 years duration. There was no visual disturbance. His height was 168cms, wt 71kg and BMI of 25Kg/ per met square.He was normotensive .Biochemical and hormonal profile revealed he was euglycemic, euthyroid, serum cortisol(am)280nmo/lit(normal 450-700nmo/lit) non suprresible GH values of 46 ng/ml with 75gms of oral glucose (normal< 1 ng ...

ea0008dp13 | Diabetes, metabolism and cardiovascular | SFE2004

HISTOPATHOLOGICAL SURPRISE IN A RADIOLOGICALLY PATIENT OF ACROMEGALY: SOMATOROPINOMA WITH NEURONAL CHORISTOMA

Dutta PD , Bhansali AB , Dradotra BDR , Singh PS

Case report;A 42-year-old male presented with headache, coarserning of facial features, enlargement of body parts of 2 years duration. There was no visual disturbance. His height was 168cms, wt 71kg and BMI of 25Kg/ per met square.He was normotensive .Biochemical and hormonal profile revealed he was euglycemic, euthyroid, serum cortisol(am)280nmo/lit(normal 450-700nmo/lit) non suprresible GH values of 46 ng/ml with 75gms of oral glucose (normal< 1 ng ...

ea0065p238 | Metabolism and Obesity | SFEBES2019

Idiopathic gigantomastia: newer mechanistic insights implicating the paracrine milieu

Das Liza , Dutta Pinaki , Rai Ashutosh , Bhansali Anil , Tripathy Satyaswarup , Vaiphei Kim , Garg Akhil , Mohsina Subair

Objective: The primary objective was to characterise the paracrine milieu in three subjects with apparently idiopathic gigantomastia and to study the relative expression of implicated factors in these pathological specimens as compared to tissue samples from normal breast, gynecomastia and breast cancer.Background: Gigantomastia refers to pathological breast enlargement usually occurring in the peripubertal or peripartum period. Idiopathic gigantomastia,...