Searchable abstracts of presentations at key conferences in endocrinology

ea0063p226 | Pituitary and Neuroendocrinology 1 | ECE2019

Metabolic fingerprint of acromegaly and its potential usefulness in clinical practice

Biagetti Betina , Herance JR , Ferrer Roser , Aulinas Anna , Mesa Jordi , Simo Rafael

Background: Acromegaly is a rare chronic and debilitating disease. More than half of patients are not well controlled and most of them require chronic surveillance. Although IGF1 and GH circulating levels are the main targets, they are not in close relationship with the behaviour of the tumour, the clinical course of the disease, the therapy response and the associated comorbidities. Metabolomics is an emergent research tool that we have used to examine in a massive manner the...

ea0063p729 | Pituitary and Neuroendocrinology 2 | ECE2019

Muscle dysfunction is associated with poor quality of life in patients with Cushing’s syndrome long-term after remission

Martel Luciana , Bascunana Helena , Cuartero Jordi , Biagetti Betina , Webb Susan M. , Valassi Elena

Background: Residual morbidity in patients with Cushing’s syndrome (CS) in remission significantly affects Quality of Life (QoL). While sustained muscle weakness is a frequent complaint in these patients, the impact of muscle dysfunction on their psychophysical wellbeing is currently unknown. Patients & methods: We included 28 female patients [mean(±SD) age, 50±12 years; mean (±SD) BMI, 26.7±3.8] and 26 age- and BMI-matched healthy controls. Mean (...

ea0037ep872 | Thyroid cancer | ECE2015

Role of thyroglobulin as a predictor of the evolution of disease in differentiated thyroid cancer

Biagetti Betina , Zafon Carles , Garcia-Burillo Amparo , Velasco Monica , Obiols Gabriel , Castell Joan , Mesa Jordi

Aim: Investigate, in patients with differentiated thyroid cancer (DTC) if thyroglobulin (Tg) values, immediately before and six months post radioiodine ablation are good predictors of disease progression.Materials and methods: Basal Tg values (Tg-B) and rhTSH stimulated Tg (Tg-S) before ablation (0) and 6 months later (6) from 142 DTC patients, with post-surgical ablation therapy between 2003 and 2009 with a follow up of 5 years, were analysed.<p cla...

ea0035p1083 | Thyroid Cancer | ECE2014

Langerhans cell histiocytosis and papillary thyroid carcinoma

Biagetti Betina , Diego Estrella , Dalama Belen , Iglesias Carmela , Gonzalez Oscar , Mesa Jordi

Introduction: Thyroid gland involvement by Langerhans Cell Histiocytosis (LCH) is a very rare condition. It occurs by thyroid infiltration that may result in hypothyroidism. LCH may be also related to neoplastic processes such as leukemias or lymphomas. However, the association with papillary thyroid carcinoma (PTC) is exceptional. We introduce a case and review the reported cases of this association.Case report: We describe a 33 year old patient diagnos...

ea0032p937 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Carbohydrate metabolism in acromegaly and treatment impact

Biagetti Betina , Valladares Silvia , Arnez Lorena , Dalama Belen , Obiols Gabriel , Mesa Jordi

Introduction: Generously supported by IPSEN)-->Carbohydrate metabolism (CHM) is impaired in over 30% of acromegalic patients. Natural history of acromegaly and treatment modalities, i.e. surgery, somatostatin analogues (SSA) and pegvisomant, may impact in a different way on CHM.Aim: To assess CHM alterations (impaired fasting glucose (IFG) and diabetes mellitus (DM)) in acromegaly and their relationship with cl...

ea0081ep821 | Pituitary and Neuroendocrinology | ECE2022

Preference of acromegaly patients for treatment attributes in Spain

Fajardo-Montanana Carmen , Alvarez Escola Cristina , Biagetti Betina , Centeno Rogelio Garci a , Ciriza Raquel , Sanchez Laura , Diaz Marcos

Background: Acromegaly is a slowly progressive rare disease caused by an increase in growth hormone secretion that causes a subsequent rise in insulin-like growth factor (IGF-1), both contributing to the excessive growth of the extremities, soft tissues and organs, in addition to other comorbidities directly interfering with patient’s quality of life. Acromegaly patients are concerned about their disease and their treatments, however, publications about patient’s opi...

ea0037ep798 | Pituitary: clinical | ECE2015

Increased serum levels of the Wnt antagonist Dicckopf-1 (DKK1) and impaired trabecular bone mineral density using QCT scan in acromegalic patients

Valassi Elena , Crespo Iris , Aulinas Anna , Urgell Eulalia , Malouf Jorge , Llauger Jaume , Marin Ana Maria , Biagetti Betina , Webb Susan M

Introduction: Acromegaly is associated with increased bone turnover and skeletal fragility. Although the GH/IGF1 system plays an important role in bone homeostasis, effects of GH excess on the Wnt signalling pathway are to be determined. Bone quantitative CT (QCT) provides a volumetric, tridimensional measure of bone mass at the trabecular and cortical level.Aim: i) To compare volumetric bone density (vBMD) using QCT in patients with acromegaly vs gender...

ea0070aep699 | Pituitary and Neuroendocrinology | ECE2020

Determinants of epicardial fat in patients with acromegaly

Biagetti Betina , Herance Raúl , Casteràs Anna , Ferrer Roser , Mesa Jordi , Simo Canonge Rafael

Background: Epicardial adipose tissue (EAT), the visceral fat of de myocardium, has been positively related to insulin resistance (IR), cardiovascular risk and the left ventricular myocardial mass. Whether EAT thickness in acromegaly is mediated by GH/IGF-1, IR or other factors remains to be elucidated.Objective: The aims of this study were: 1) To investigate whether EAT in patients with ACRO is linked to IR and pro-inflammatory and anti-inflammatory rel...

ea0090p276 | Adrenal and Cardiovascular Endocrinology | ECE2023

The impact of Bariatric Surgery on the 1mg Dexamethasone Suppression Test in patients with Severe Obesity

Casteras Anna , Fidilio Enzamaria , Comas Marta , Michael Ortiz Angel , Biagetti Betina , Zabalegui Alba , Filippi Francesca , Giralt Marina , Ferrer Roser , Vilallonga Ramon , Ciudin Andreea

Background: The cortisol suppression test with 1 mg dexamethasone (DST) is a screening test for hypercortisolism with high sensitivity (95%) for serum cortisol cut-off <1.8 μg/dl. However, cortisol tests may give false positive in patients with severe obesity (SO). On the other hand, bariatric surgery (BS) is the most effective treatment for SO, and the operated population is growing. At present there is no reliable data regarding the impact of BS on DST results in pa...

ea0063gp159 | Cushing's | ECE2019

Skeletal muscle fatty infiltration in the thigh, as assessed by MRI T2-weighted and 3-point Dixon sequences, is associated with poor performance on muscle function testing in patients with Cushing’s syndrome in remission

Martel Luciana , Alonso Alicia , Bascunana Helena , Manera Jordi Diaz , Llauger Jaume , Nunez-Peralta Claudia , Biagetti Betina , Montesinos Paula , Webb Susan , Valassi Elena

Background: Muscle weakness may persist in patients with Cushing’s syndrome (CS) long-term after resolution of hypercortisolism, but mechanisms determining this sustained impairment are not known. We hypothesized that alteration of muscle structure, due to fatty infiltration, is associated with muscle dysfunctions in these patients.Patients & methods: Twenty-six CS women [mean(±S.D.) age 49±12 years; mean(±S....