ea0037gp.09.01 | Nuclear receptors and signalling | ECE2015
Brtko Julius
, Bialesova Lucia
, Lenko Vladimir
, Galbavy Stefan
, Podoba Jan
, Macejova Dana
Introduction: Nuclear retinoid receptors (RARs) upon a ligand binding act as all-trans retinoic acid-inducible transcription factors interacting as heterodimers with nuclear retinoid X (rexinoid) receptors (RXRs). The disruption of retinoic acid (RA) signalling pathways is believed to underlie the etiology of a number of malignancies. Retinoids cell differentiation agents that may reprogram tumours, i.e. retinoic acid derivatives or retinoic acid related com...