Searchable abstracts of presentations at key conferences in endocrinology

ea0090p265 | Late-Breaking | ECE2023

Genetic profile of bone metabolism and immunity modulators in bone metastasis in castration-resistant prostate cancer

Janeiro Matthew , Matos Andreia , Medeiros Rui , Bicho Manuel , Ribeiro Ricardo

Introduction: Prostate cancer is a neoplasm with high incidence and prevalence in the elderly population in western countries. Androgen deprivation therapy (ADT) has been used in locally advanced or metastatic disease, although most relapse, becoming hormone resistant, which is a poor prognostic event.Objectives: The aim of this study was to evaluate the association of genetic polymorphisms NOS2, GPRC6A, VKORC1, ARGI and ARGII in prostate cancer, particu...

ea0081p611 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Influence of dopamine receptor d2 and dopamine transporter polymorphisms in angiopathy in patients with type 2 diabetes mellitus

Neves Marta , Santos Ana Carolina , Ferreira Joana , Raposo Joao F. , Valente Ana , Bicho Manuel

Introduction and Aim: Dopamine receptor D2 (DRD2) polymorphism (rs1800497) appears to be associated with increased susceptibility to the development of type 2 diabetes mellitus (T2DM). The dopamine transporter (DAT) determines dopamine signalling, responsible for the reuptake of its active form from the synapse. Polymorphism in the DAT gene (rs2836317) can increase dopamine reuptake in the synaptic cleft. However, its association with T2DM is still controversial.<p class="...

ea0090p40 | Calcium and Bone | ECE2023

Polymorphisms in genes related to iron metabolism and DNA methylation and their interaction with estradiol in susceptibility to osteoporosis in postmenopausal women

Aguiar Laura , Ferreira Joana , Paula Barbosa Ana , Rui Mascarenhas Mario , Faustino Paula , Inacio Angela , Bicho Manuel

Introduction: Osteoporosis is a multifactorial disease characterized by reduced bone mass and increased risk of fragility fractures. Menopause predisposes women to osteoporosis due to declining estrogen levels. Iron is known to play a relevant role in the development of osteoporosis since iron suppresses osteoblast formation and may also stimulate osteoclast resorption of bone. Also, homocysteine is a known risk factor for osteoporotic fractures and is related to DNA methylati...

ea0063p1028 | Interdisciplinary Endocrinology 2 | ECE2019

Impact of hormonal factors in the genesis of sarcopenia

Mascarenhas Mario Rui , Barbosa Ana Paula , Fortes Indira , Ferreira Joana , Bicho Manuel

The European Working Group on Sarcopenia in Older People (EWGSOP2) defined in 2018 ‘sarcopenia as muscle disease (muscle failure), with low muscle strength overtaking the role of low muscle mass as a principal determinant’; sarcopenia increases risk of falls and fractures, impairs ability to perform activities of daily living, leads to mobility disorders and low quality of life and death. The diagnosis is confirmed by low muscle quantity or quality. The muscle quanti...

ea0049ep232 | Bone &amp; Osteoporosis | ECE2017

May serotonin metabolism polymorphisms 5HTTVNTR and 5HT2A have a clinical impact in osteoporosis development?

Simoes Raquel , Freitas Joana , Barbosa Ana Paula , Mascarenhas Rui , Bicho Manuel

Objectives: To study the association of serotonin transporter gene (SLC6A4) polymorphism 5HTTVNTR and serotonin receptor 2A polymorphism 5HT2A_T102C with bone mineral density and metabolic parameters of bone remodelling.Materials and methods: BMD (g/cm2) was measured by DEXA in 105 post-menopausal women: 35 with normal BMD (age=58.30±1.33 years; BMI=28.18 [19.13-39.87] kg/m2) and 70 with osteoporosis (age=68.30±1.09 years; BMI=28.90 ...

ea0049ep234 | Bone &amp; Osteoporosis | ECE2017

Beta-2 adrenergic receptor (ADRB2) gene polymorphism Arg16Gly as risk factor for osteoporosis

Simoes Raquel , Freitas Joana , Barbosa Ana Paula , Mascarenhas Mario , Bicho Manuel

Objectives: To study the association of Beta-2 adrenergic receptor (ADRB2) gene polymorphism Arg16Gly with bone mineral density and metabolic parameters of bone remodelling.Materials and methods: BMD (g/cm2) was measured by DEXA in 105 post-menopausal women: 35 with normal BMD (age=58.30±1.33 years; BMI=28.18 [19.13-39.87] kg/m2) and 70 with osteoporosis (age=68.30±1.09 years; BMI=28.90 [20.78-43.86] kg/m2). Met...

ea0049ep562 | Diabetes complications | ECE2017

Biomarkers status and their relation with the presence of type 2 diabetes with and without angiopathy

Valente Ana , Bicho Manuel , Duarte Rui , Raposo Joao , Costa Helena Soares

Introduction: A useful tool for disease clinical characterization and treatment of type 2 diabetes is the knowledge on the status of several biomarkers. The aim of this study was to evaluate the levels of cardiovascular, oxidative stress and nutritional biomarkers and their relationship with the presence of type 2 diabetes and angiopathy.Methods: A population-based case-control study in 150 Portuguese type 2 diabetic patients was performed. Group I &#150...

ea0049ep632 | Endocrine Disruptors | ECE2017

Bone-to-muscle endocrine axis modulating adaptation to exercise in athletes of mountain cycling in a Portuguese Marathon

de Alonso Isanete Alves , Matos Andreia , Gil Angela , Cardoso Carlos , Sardinha Luis Bettencourt , Bicho Manuel

Introduction: Besides the benefits of low-to-high intensity physical activity (PA) on metabolism, it is currently emerging that excessive PA can be deleterious with serious implications not only in muscle but also, bone remodeling. Despite recent findings remains still unclear and controversial, we hypothesize that exercise of impact, like mountain cycling, beyond influencing the metabolic and skeletal profile, represents an important model of profoundly changes in bone metabo...

ea0037ep538 | Diabetes (complications &amp; therapy) | ECE2015

Contribution of haptoglobin and MTHFR polymorphisms to hyperhomocysteinemia and hypercysteinemia in type 2 diabetic patients

Valente Ana , Bicho Manuel , Garcia Ana , Goncalves Conceicao , Duarte Rui , Raposo Joao F , Costa Helena S

Introduction: There is a lack of epidemiological data on the distribution of haptoglobin and C677T of MTHFR polymorphisms in Caucasians type 2 diabetic patients. The contribution of these two genetic factors to hyperhomocysteinemia and hypercysteinemia can be useful to prevent cardiovascular events and to reduce public health costs. The aim of this study is to evaluate the contribution of haptoglobin and C677T polymorphisms for hyperhomocysteinemia and hypercysteinemia in Port...

ea0032p679 | Neuroendocrinology | ECE2013

DHEA enhances working memory and prevents distraction: behavioural and ERP evidence from an auditory–visual distraction paradigm

Vale Sonia , Selinger Lenka , Martin Martins Joao , Bicho Manuel , Carmo Isabel , Escera Carles

Introduction: Several studies suggest DHEA and DHEAS (DHEA(S)) are related to memory enhancement and a better performance under stress. An anti-cortisol action may contribute to those relations. We looked for a new level of evidence, by studying DHEA(S) and cortisol relations to working memory (WM) and distraction in humans also at the electrophysiological level.Subjects and methods: Twenty-eight healthy female volunteers (18–26 years old) were pres...