Searchable abstracts of presentations at key conferences in endocrinology

ea0086p3 | Adrenal and Cardiovascular | SFEBES2022

Identification and characterization of a receptor for N-terminal pro-opiomelanocortin peptide

Alshammari Fatema , Bicknell Andrew , Lander Elizabeth

Background: Numerous studies have reported the role of the N-terminal of pro-opiomelanocortin (N-POMC1-76) and its smaller fragments; 1-28 and 1-49, in adrenal steroidogenesis and mitogenesis. A full understanding of this area will help to understand the pathophysiology of certain adrenal tumours but exactly how these peptides elicit this effect is unclear. We have recently identified an orphan G protein-coupled receptor (GPCR) as a possible N-POMC receptor. Preliminary data s...

ea0086p11 | Adrenal and Cardiovascular | SFEBES2022

Development of novel immunoassays for pro-opiomelanocortin (POMC)-derived peptides as surrogate markers of adrenocorticotrophin levels for use in the diagnosis of Cushing’s syndrome

Donnelly Megan , Lowry Philip , Gibbins Jon , Bicknell Andrew

Plasma adrenocorticotrophin (ACTH) is extremely labile and far from an ideal analyte for use in the diagnosis of Cushing’s syndrome. Processing of ACTH by some ectopic tumours releases high levels of smaller ACTH-like fragments, α-MSH and CLIP, which can interfere with individual antibodies in current diagnostic immunoassays. Furthermore, cross-reactivity with the precursor of ACTH, pro-opiomelanocortin (POMC), increases the likelihood of erroneous interpretations an...

ea0038p390 | Steroids | SFEBES2015

Alpha-MSH secretion from a gastro-intestinal stromal tumour leading to ACTH-independent Cushing’s syndrome

Cavlan Dominic , Drake William , Lowry Phil , Bicknell Andrew , Evagora Christopher , King Peter

A 51 year old woman presented with severe Cushing’s syndrome. In addition to a typically Cushingoid appearance she demonstrated increased cutaneous pigmentation in her face and upper chest. Biochemical investigation confirmed elevated serum cortisol levels with loss of circadian variation, and failure to suppress with low dose dexamethasone (0.5 mg 6 hourly for 48 hours). Serum ACTH levels were undetectable. Cross-sectional imaging revealed bilateral macronodular adrenal ...