Searchable abstracts of presentations at key conferences in endocrinology

ea0044oc4.5 | Adrenal and Steroids | SFEBES2016

ARID1a is required for regulation of a subset of glucocorticoid target genes involved in cell-cycle and p53 pathway regulation

Stubbs Felicity E. , Birnie Matthew T. , Fang Hai , Biddie Simon C. , Lightman Stafford L. , Conway-Campbell Becky L.

Clinically, glucocorticoids are widely used as a treatment mainly due to their potent anti-inflammatory abilities, however these are associated with several side effects and furthermore some patients go on to develop glucocorticoid resistance. ARID1a mutations have been linked to glucocorticoid resistance and are frequently identified across numerous cancers; therefore it is important to determine the functional role of ARID1a to GR signalling. The ATPase driven SWItch/Sucrose...