Searchable abstracts of presentations at key conferences in endocrinology

ea0025p268 | Reproduction | SFEBES2011

In support of the ‘Rotterdam’ PCOS criteria: Identical LH responses to GnRH stimulation in women with oligo-/amenorrhoea and polycystic ovaries regardless of androgen status

Lewandowski Krzysztof , Cajdler-Luba Agata , Bienkiewicz Malgorzata , Lewinski Andrzej

Objective: There is no universal consensus as to the criteria of PCOS (i.e. Rotterdam ESHRE/ASRM versus Androgen Excess Society (AES) criteria). Furthermore, androgen measurements within the female range are fraught with several methodological problems. As GnRH stimulation can reveal a relative LH excess, caused by an increased frequency of hypothalamic GnRH pulses, then we have endeavoured to assess gonadotrophin response to GnRH in women with PCOS and healthy controls...

ea0022p458 | Female reproduction | ECE2010

GnRH test as an additional investigation in the diagnosis of polycystic ovary syndrome (PCOS): potential application of stimulated LH/FSH ratio

Cajdler-Luba Agata , Lewandowski Krzysztof , Bienkiewicz Malgorzata , Salata Ireneusz , Lewinski Andrzej

Diagnosis of PCOS may be sometimes difficult, e.g. due to limited sensitivity of androgen assays and discrepancies in interpretation of ovarian ultrasound imaging. As GnRH stimulation test can reveal a relative LH excess, then we have endeavoured to assess whether this test might be useful in the diagnosis of PCOS.Patients and methods: The study involved 154 subjects: PCOS group, n=120, age (mean±S.D.) 24.8±5.4 years, BMI ...

ea0021p132 | Diabetes and metabolism | SFEBES2009

Positive correlation between serum omentin and thrombospondin-1 in gestational diabetes despite lack of correlation with insulin resistance indices

Lewandowski Krzysztof , Cypryk Katarzyna , Nadel Iwona , Lewinski Andrzej , Bienkiewicz Malgorzata , Tan Bee , Randeva Harpal

Background: Gestational diabetes (GDM) is characterized by insulin resistance and a pro-inflammatory state, both factors possible related to adipokine expression. In our study we have endeavoured to assess serum levels of insulin-sensitising omentin and pro-inflammatory thrombospondin-1 (TSP-1) in GDM.Subjects and methods: The study included 20 women with GDM, diagnosed according to the WHO criteria, age 29.7±5.5 (mean±S.D.), BMI...

ea0016p500 | Obesity | ECE2008

Retinol-binding protein 4 (RBP-4) levels do not change after oral glucose tolerance test in obese and overweight individuals, but correlate with some indices of insulin resistance

Lewandowski Krzysztof C , Basinska-Lewandowska Magdalena , Bienkiewicz Malgorzata , Randeva Harpal S , Lewinski Andrzej

Background: Secretory products from adipocytes may contribute to increased insulin resistance (IR). Retinol-binding protein-4 (RBP-4) may increase IR in mice, with elevated levels in insulin resistant mice and humans with obesity and type 2 diabetes. Mechanisms regulating RBP-4 synthesis remain not fully understood. It is not clear whether short-term hyperglycaemia alters RBP-4 levels in humans. In order to investigate this, we measured serum RBP-4 concentrations during 75 gra...

ea0037ep132 | Reproduction, endocrine disruptors and signalling | ECE2015

How much insulin resistance in polycystic ovary syndrome: comparison of HOMA and insulin resistance (Belfiore) index models

Lewandowski Krzysztof , Lukasiak Katarzyna , Marczuk Katarzyna , Dukowicz Aleksandra , Cedro Magdalena , Bienkiewicz Malgorzata , Skowronska-Jozwiak Elzbieta , Lewinski Andrzej

Background: Polycystic ovary syndrome (PCOS), the commonest endocrinopathy of women in the reproductive age is often accompanied by insulin resistance (IR). The aim of the study was to assess the prevalence of IR in women diagnosed with PCOS, where IR was assessed by methods most commonly used in clinical practice, i.e. homeostatic model assessment (HOMA) and insulin resistance index (IRI), also known as the Belfiore index.Patients and methods: The study...