Searchable abstracts of presentations at key conferences in endocrinology

ea0035s11.1 | Long term outcome of cured pituitary patients | ECE2014

Long-term outcome of ‘cured’ patients: acromegaly

Biermasz Nienke

Active acromegaly is associated with considerable morbidity and increased mortality. Multimodality treatment of acromegaly is nowadays effective in the vast majority of patients and consequently survival of acromegaly has improved/normalized.Nevertheless, significant chronic physical and psychological complaints persist in the long-term follow-up after cure of acromegaly and quality of life in patients has reported to remain significantly reduced despite...

ea0063p1039 | Interdisciplinary Endocrinology 2 | ECE2019

The role of the growth hormone – insulin-like growth factor 1 axis in primary osteoarthritis

Pelsma Iris , Claessen Kim , Ramos Yolande , Meulenbelt Ingrid , Biermasz Nienke

Introduction: Increased insulin-like growth factor 1 (IGF-1) levels in patients with acromegaly are associated with clinical and radiological osteoarthritis (OA). We aimed to elucidate whether serum IGF-1 levels differ in patients with primary OA as compared to healthy controls and whether genetic variants known to affect serum IGF-1 levels are also associated with primary OA.Methods: Patients from the GARP study with familial generalized OA (n=...

ea0037gp.01.07 | Adrenal | ECE2015

Mild cognitive deficits in patients on long-term, stable hydrocortisone replacement for primary adrenal insufficiency: a case–control study

Andela Cornelie , Tiemensma Jitske , Biermasz Nienke , Romijn Johannes , Pereira Alberto

Background: Hydrocortisone replacement for primary adrenal insufficiency (PAI) is targeted to mimic circadian endogenous cortisol secretion. Nevertheless, patients on stable treatment report impairments in quality of life. The brain is a major target area for cortisol considering it high density of glucocorticoid receptors and previous studies in patients treated for Cushing’s disease (CD) suggest that hypothalamic-pituitary-adrenal axis dysregulation is related to cognit...

ea0063p704 | Pituitary and Neuroendocrinology 2 | ECE2019

Sex differences in presentation but not in outcome for ACTH-dependent Cushing’s syndrome

Broersen Leonie , Haalen Femke van , Kienitz Tina , Biermasz Nienke , Strasburger Christian , Dekkers Olaf , Pereira Alberto

Background: Sex differences in clinical picture of ACTH-dependent Cushing’s syndrome are controversial, except for the known higher prevalence in females. We compared a broad range of potential differences to enable a more accurate understanding of the clinical picture of sex-specific ACTH-dependent Cushing’s syndrome.Design: Cohort study.Methods: We included consecutive patients with ACTH-dependent Cushing’s syndrom...

ea0063p705 | Pituitary and Neuroendocrinology 2 | ECE2019

Adrenal crisis in treated patients with Cushing’s syndrome

Broersen Leonie , Haalen Femke van , Kienitz Tina , Dekkers Olaf , Strasburger Christian , Pereira Alberto , Biermasz Nienke

Background: Adrenal crisis, the most feared complication of adrenal insufficiency, is a potentially life-threatening situation of acute glucocorticoid deficiency. After successful surgery, many patients with Cushing’s syndrome develop (transient) adrenal insufficiency. The incidence of adrenal crisis in patients treated for hypercortisolism is unknown.Methods: Cohort study including consecutive patients with Cushing’s syndrome with adrenal insu...

ea0041gp151 | Pituitary - Clinical | ECE2016

Longitudinal assessment of response to treatment with oral octreotide capsules in patients with acromegaly: post-hoc analysis of a phase 3 trial

Fleseriu Maria , Melmed Shlomo , Mangal Brian , Strasburger Christian J , Biermasz Nienke R

Introduction: Although biochemical markers of acromegaly disease activity, including GH and IGF1, may fluctuate from day-to-day, biochemical treatment response in clinical trials is generally monitored using single-point analyses. Accordingly, longitudinal evaluations may assess patient status more accurately. In a phase 3 trial, oral octreotide capsules (OOC) demonstrated sustained composite endpoint GH and IGF1 response for ≤13 months in 151 patients with acromegaly pr...

ea0041gp159 | Pituitary - Clinical (1) | ECE2016

The partner perspective of the impact of pituitary disease: results from a focus group study

Andela Cornelie , Tiemensma Jitske , Kaptein Adrian , Scharloo Margreet , Pereira Alberto , Kamminga Noelle , Biermasz Nienke

Background: Patients with pituitary disease demonstrated Quality of Life (QoL) impairment. From other chronic diseases it is known that partners of patients also report impairments in QoL. Furthermore, it is observed that well-being of patients is associated with the well-being of their partners. To date, no data are available on the well-being of partners of patients with pituitary disease. Therefore, the aim of the present study was to explore well-being of partners of patie...

ea0037ep749 | Pituitary: clinical | ECE2015

The development and validation of a new burden and needs assessment questionnaire for patients with pituitary diseases: the BNQ-pituitary

Andela Cornelie , Scharloo Margreet , Ramondt Steven , Tiemensma Jitske , Kaptein Ad , Pereira Alberto , Kamminga Noelle , Biermasz Nienke

Background: An increasing number of studies assess quality of life (QoL) in patients with pituitary diseases. At present, available disease-specific QoL questionnaires do not completely cover the patient perspective of QoL. Furthermore, there are no disease-specific questionnaires available which inventories patient’s needs for help for impairments in QoL.Objective: To develop and validate a disease-specific QoL questionnaire for patients with pitui...

ea0070ep295 | Pituitary and Neuroendocrinology | ECE2020

Pre-operative full blood count, C-reactive protein and serum inflammation-based scores may predict aggressive or refractory disease in patients with pituitary adenomas

Marques Pedro , de Vries Friso , van Furth Wouter , Korbonits Marta , Biermasz Nienke , Pereira Alberto M

Introduction: Full blood count (FBC), C-reactive protein (CRP), albumin and serum inflammation-based scores reflect systemic inflammation and predict outcomes in oncological patients. While these are increasingly used in cancer, little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in patients with PAs and investigate the usefulness of such parameters in predicting aggressive/refractory disease.Methods: W...

ea0022p554 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Increased prevalence of psychopathology and maladaptive personality traits in patients after long-term cure of Cushing's disease

Tiemensma Jitske , Biermasz Nienke , Middelkoop Huub , van der Mast Roos , Romijn Johannes , Pereira Alberto

Objective: Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing’s disease (CD). We hypothesized that patients with long-term cure of CD show persistent psychopathology and maladaptive personality traits.Aim: To evaluate psychopathology and personality traits in patients with long-term cure of CD.Patients and methods: We included 67 patients cured of CD (15% males, mean age 53...