Searchable abstracts of presentations at key conferences in endocrinology

ea0007p208 | Steroids | BES2004

The testicular feminised mouse: physiological testosterone replacement

Nettleship J , Biggins C , Jones R , English K , Channer K , Jones T

Testicular feminised (Tfm) mice bear an X-linked, single base pair deletion in the gene encoding the classical androgen receptor(1) consequently these animals express a truncated, non-functional form of the receptor protein. Affected animals (XTfmY) are rendered insensitive to actions mediated via this receptor. The Tfm mouse is therefore an excellent model for studying non-genomic testosterone signalling mechanisms. Unfortunately, Tfm mice are also deficient in the...