Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep428 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Adiponectin and omentin-1 concentrations in patients with systemic sclerosis

Bik Wojciech , Dopytalska Klaudia , Kalisz Małgorzata , Litwinuk Anna , Baranowska-Bik Agnieszka , Walecka-Herniczek Irena

Adipokines belong to a group of proteins involved in the pathogenesis and progression of immune/inflammatory diseases. It is an open question whether and how adipokines contribute to these diseases. Adiponectin might be a key regulator of the immune system, playing a role in the progression of inflammatory disorders. Omentin has been recognized as an anti-inflammatory adipokine with influence on immune response regulation and inflammation, Systemic sclerosis (SSc) is a chronic...

ea0014p640 | (1) | ECE2007

The effects of cycloheximide, actinomycine D and indomethacin on progesterone release stimulated by PACAP 38 from cultured rat ovarian granulosa cells

Wasilewska-Dziubinska Elzbieta , Chmielowska Magdalena , Wolinska-Witort Ewa , Martynska Lidia , Bik Wojciech , Baranowska Boguslawa

Neuropeptide PACAP 38 expressed in steroidogenic ovarian cells of rat could be an auto- or paracrine regulator of progesterone synthesis. Moreover, it has been shown that PACAP38 can affect ovarian secretion of prostaglandins. The first and rate-limiting step in the biosynthesis of progesterone is the transfer of cholesterol into mitochondria which is facilitated by the cycloheximide-sensitive steroid acute regulator (StAR) protein. StAR protein has been established as an esse...

ea0049ep908 | Neuroendocrinology | ECE2017

Decreased prolactin levels in plasma and cerebrospinal fluid in naïve to treatment patients with multiple sclerosis

Baranowska-Bik Agnieszka , Uchman Dorota , Martynska Lidia , Kalisz Malgorzata , Litwiniuk Anna , Bik Wojciech , Baranowska Boguslawa , Kochanowski Jan

Background: Data from the literature has documented a remarkable immune-modulating role of prolactin. Previous evaluations of prolactin levels in patients with multiple sclerosis (MS), disease of autoimmune origin, showed conflicting results. Thus, to clarify the impact of prolactin on MS pathology we decided to assess prolactin levels in plasma and cerebrospinal fluid in naïve to treatment subjects with newly diagnosed MS.Material and methods: A to...

ea0014p248 | (1) | ECE2007

Neuroendocrine and genetic aspects of metabolic disturbances in women with simple obesity, polycystic ovary syndrome (PCOS) and eating disorders

Baranowska-Bik Agnieszka , Bik Wojciech , Wolinska-Witort Ewa , Gaj Pawel , Mikula Michal , Bragoszewski Piotr , Ostrowski Jerzy , Baranowska Boguslawa

Neuropeptides and adipocytokines influence metabolic homeostasis and food intake. Deregulation in their secretion leads to insulin resistance or metabolic syndrome. Adiponectin possesses anti-diabetic and insulin sensitizing properties. Expression of this gene remains under control of nuclear peroxisome proliferator-activated receptor (PPAR)-gamma. Ghrelin, an endogenous ligand for GH secratagogue receptor (GHSR), modulates metabolic homeostasis. A high amino-acid homology and...