Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1038 | Thyroid (non-cancer) | ECE2014

Thyroglobulin as a biomarker of iodine deficiency

Bilek Radovan , Cerovska Jarmila , Zamrazil Vaclav

Introduction: We are presenting our results on the relationship between a concentration of urinary iodine (UI) and serum thyroglobulin (Tg) in population studies carried out on a general healthy total population that was randomly selected (individuals aged 6–98 years, 1751 males, 2420 females). 87.2% of the total population was described as the normal population with a simultaneously determined thyrotropin and free thyroxine within reference ranges....

ea0022p326 | Diabetes | ECE2010

Pancreatic insulin secretion in women with polycystic ovary syndrome

Vrbikova Jana , Bilek Radovan , Vankova Marketa , Vondra Karel , Bendlova Bela

Aim: To study the insulin sensitivity and secretion in women with polycystic ovary syndrome (PCOS).Subjects and methods: Thirty-eight women with PCOS (age 26.1±4.1 years, BMI 20.9±2.0 kg/m2) and 81 control healthy women (age 25.8±5.2 years, BMI 21.1±2.3 kg/m2) underwent oral glucose tolerance test (OGTT). Insulin resistance was evaluated as oral glucose index (OGIS); Matsuda and HOMA-IR, insulin secretion was cal...

ea0032p1012 | Thyroid (non-cancer) | ECE2013

Iodine status in women after early miscarriages in the Czech Republic

Jiskra Jan , Fait Tomas , Bilek Radovan , Bartakova Jana , Potlukova Eliska , Springer Drahomira , Telicka Zdenek , Limanova Zdenka

Background: Early miscarriages are of multifactorial origin. Subclinical thyroid dysfunction belongs to the common causes. Thyroid dysfunction in pregnancy is caused mainly by thyroid autoimmunity and/or iodine deficiency. The Czech Republic belongs to countries with sufficient iodine intake. The aim of the study was to determine iodine status in women after early miscarriages (n=183) and to compare it with randomly chosen age-comparable euthyroid women without previo...

ea0022p357 | Diabetes | ECE2010

Levels of adrenomedullin during low dose Synacthen test in diabetics type 1

Simunkova Katerina , Bilek Radovan , Hampl Richard , Zamrazil Vaclav , Janickova-Zdarska Denisa , Hill Martin , Vondra Karel

The aim of the study was to obtain the basic data about adrenomedullin after 1 μg ACTH stimulation.Adrenomedullin has direct effect on adrenal cortex secretion, therefore we studied the changes of its concentrations during ACTH stimulation in diabetic patients suspected of hypocorticalism.Thirty-two diabetics type 1 (DM1) were investigated; 16 with and 16 without autoimmune thyroditis (AIT); age 44±10 years (mean±<sm...

ea0014oc3.4 | Endocrine tumors &amp; neoplasia | ECE2007

RET mutation – Tyr791Phe – the genetic cause of different diseases derived from neural crest

Vaclavikova Eliska , Dvorakova Sarka , Vlcek Petr , Skaba Richard , Bilek Radovan , Bendlova Bela

Familial medullary thyroid carcinoma (MTC), multiple endocrine neoplasia types 2A and 2B (MEN2A, 2B) and Hirschsprung disease (HSCR) are inherited neurocristopathies linked to germline mutations in the RET proto-oncogene. Activating germline RET mutations are presented in patients with FMTC, MEN2A and MEN2B, on the other hand, inactivating germline mutations in patients with HSCR. Nevertheless, there is an overlay in specific mutations in the exon 10 of the RET proto-oncogene....