Searchable abstracts of presentations at key conferences in endocrinology

ea0099p248 | Calcium and Bone | ECE2024

Comparison of fractional excretion of calcium from different urine samples in the differentiation between primary hyperparathyroidism and familial hypocalciuric hypercalcemia

Koster Markus , Martin Siegenthaler , Stefan Bilz

Background: Calculation of the fractional excretion of calcium (FECa) from 24-hour (24h) urine collections is recommended to identify patients with suspected familial hypocalciuric hypercalcemia (FHH) during the work-up of primary hyperparathyroidism (pHPT). The current study was designed to test whether calculating the FECa or calcium-to-creatinin clearance obtained from 24h urine specimen can be substituted by results obtained from second morning or spontaneous void urine sa...

ea0041ep1016 | Thyroid (non-cancer) | ECE2016

Total thyroidectomy in refractory amiodarone induced thyrotoxicosis: a case series of 12 patients

Drescher Tilman , Clerici Thomas , Kolb Walter , Brandle Michael , Bilz Stefan

Introduction: Amiodarone induced thyrotoxicosis (AIT) occurs in 5–10% of patients and may occur at any time throughout the course of treatment including months after discontinuation. Two distinct forms of AIT are distinguished and treated differently. Iodine-induced hyperthyroidism, typically seen in patients with underlying thyroid disease, is referred to as typ1 AIT and treated with high doses of thionamide antithyroid drugs and perchlorate. Type 2 AIT is a destructive ...

ea0099p250 | Calcium and Bone | ECE2024

Cystic parathyroid adenomas – a rare case of primary hyperparathyroidism: Two case reports

Veraguth Katja , Kolb Walter , Maas Ole , Bilz Stefan

Less than 0.5% of parathyroid lesions are cysts out of which only 10–20% are endocrine active. Depending on their localisation, the most frequent symptom of a parathyroid cyst (PC) is neck mass (41.7%) with possible compressive symptoms. Women are more frequently affected and tend to have hormone-inactive PCs. Men tend to have endocrine-active PCs. The best diagnostic approach is still under debate as PCs are relatively rare.Case report 1: A 68-year...

ea0037ep312 | Calcium and Vitamin D metabolism | ECE2015

Comparative diagnostic value of ultrasound, ultrasound-guided fine needle aspiration and sestamibi scintigraphy for the correct preoperative localisation of parathyroid adenomas

Bilz Stefan , Rogowski-Lehmann Nathalie , Krull Ina , Brandle Michael , Oettli Rene , Kolb Walter , Clerici Thomas

Background: This study prospectively assessed the sensitivity and positive predictive value (PPV) of ultrasound (US), ultrasound-guided fine needle aspiration with PTH measurement in the needle washout (US-FNA) and sestamibi scintigraphy (SS) for the localisation of parathyroid adenomas in patients with primary hyperparathyroidism (pHPT) and features of uniglandular disease.Methods: 51 consecutive patients with pHPT referred for first time surgery with a...

ea0037ep1267 | Clinical Cases–Thyroid/Other | ECE2015

Noninfectious but genetic bilateral neck swelling

Joel Capraro , Wolfgang Nagel , Thomas Clerici , Sandro Stockli , Michael Brandle , Stefan Bilz

Introduction: We describe a case of a 32 year old woman with bilateral carotid body tumours as initial finding of a paraganglioma syndrome type 1.Case: A 32-year old previously healthy mother was referred because of bilateral neck swelling, presumably lymphadenopathy, associated with recurrent upper respiratory tract infections during the past year. Cervical ultrasound raised the suspicion for bilateral carotid body tumours which were confirmed by MR-ima...

ea0070aep465 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Adherence with lipid treatment guidelines in Swiss patients with diabetes mellitus – results from the SwissDiab study

Singeisen Hélène , Renstroem Frida , Braendle Michael , Bilz Stefan

Introduction: The major cause of death and disability in patients with diabetes mellitus is atherosclerotic cardiovascular disease (ASCVD). Therefore, treatment guidelines specify strict target lipid levels for these patients. The aim of this study is to evaluate the adherence of diabetes mellitus type 1 and 2 patients (DM1 and DM2, respectively) with respect to the European and Swiss lipid treatment guidelines (ESC/EAS and AGLA, respectively).Methods: T...

ea0032p931 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Idiopathic isolated ACTH deficiency presenting with severe hyponatraemia

Drescher Tilman , Ackermann Christoph , Batscher Irene , Krull Ina , Brandle Michael , Bilz Stefan

Introduction: Generously supported by IPSEN)-->Acquired isolated ACTH deficiency with normal secretion of the remaining pituitary hormones is a rare condition in the absence of exposure to exogenous glucocorticoids. The aetiology is assumed to be autoimmune in most adult cases with traumatic brain injury and radiation exposure being rare causes. Pituitary transcription factor mutations may be identified in congenital and childhood on...

ea0022p551 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Combined endoscopic and pharmacologic treatment of a suprasellar arachnoid cyst associated with macroprolactinoma

Fournier Jean-Yves , Bilz Stefan , Schimke Kathrin , Krull Ina , Tasman Jan , Braendle Michael , Hildebrandt Gerhard

A 58-year-old male patient presented with a 2 months history of bilateral frontotemporal headache, fatigue and impaired vision. Further exploration revealed short term memory losses, confusion, gait disturbances, decreased libido and erectile dysfunction. Radiological investigation showed a 4 cm pituitary mass with destruction of the upper clivus and left petrous apex associated with a 5 cm large suprasellar cyst bulging upward into the 3d ventricle with obstruction hydrocepha...

ea0092ps2-16-08 | Thyroid Cancer clinical 2 | ETA2023

Lobectomy outcomes in patients with low-risk differentiated thyroid cancer: oncologic and safety outcomes at a swiss tertiary referral center

Sinz Stefanie , Bilz Stefan , Kolb Walter , Clerici Thomas , Christopher Maas Ole

Background: Recent guidelines recommend lobectomy (LOB) when compared to total thyroidectomy (TTX) as the preferred approach for patients with low-risk differentiated thyroid cancer (DTC). Major advantages are the avoidance of lifelong hormone replacement therapy and the absence of any risk for contralateral recurrent laryngeal nerve palsy and postoperative hypoparathyroidism with no or minimal increased risk for adverse oncological outcomes. However, this limited approached s...

ea0081rc8.4 | Rapid Communications 8: Calcium and Bone | ECE2022

Accuracy, costs and radiation exposure of current preoperative localization procedures in patients with primary hyperparathyroidism, a retrospective cohort study in a Swiss tertiary referral center

Siegenthaler Martin , Christopher Maas Ole , Renstrom Frida , Clerici Thomas , Forrer Flavio , Kolb Walter , Sinz Stefanie , Bilz Stefan

Background: Focused parathyroidectomy has become the standard procedure for patients with sporadic primary hyperparathyroidism (pHPT) fulfilling the criteria for surgical therapy and requires preoperative localization procedures. Ultrasound imaging (US) and 99mTc-sestamibi-scintigraphy with/without SPECT/CT (SC) are established first line procedures. 18F-choline PET/CT (PET) has emerged as a novel sensitive and specific method. However, current reimbursem...