Searchable abstracts of presentations at key conferences in endocrinology

ea0081p663 | Pituitary and Neuroendocrinology | ECE2022

GH-secreting pituitary adenoma: dura mater invasion is not a predictor of acromegaly persistence after trans-sphenoidal surgery

Prencipe Nunzia , Diperna Giuseppe , MARIA BERTON ALESSANDRO , Baldassarre Bianca , Bona Chiara , De Marco Raffaele , Bioletto Fabio , Grottoli Silvia , Zenga Francesco

Background: Despite the benign nature of pituitary adenomas, microscopic examination of surgical specimens showed that dural invasion occurs in about 42-85% of cases. No studies about dura mater invasion were conducted specifically in acromegaly, so the aim of the present study was to evaluate the relationship between histologically verified dural invasion and the “aggressiveness” features of GH-secreting adenomas.Methods: A prospective study i...

ea0081rc7.2 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Development and internal validation of a predictive score for the diagnosis of central adrenal insufficiency when morning cortisol is in the grey zone

Bioletto Fabio , Maria Berton Alessandro , Varaldo Emanuele , Cuboni Daniela , Bona Chiara , Parasiliti Caprino Mirko , Prencipe Nunzia , Ghigo Ezio , Grottoli Silvia , Maccario Mauro , Gasco Valentina

Background: When evaluating a patient for central adrenal insufficiency (CAI), there is a wide range of morning cortisol values for which no final conclusion on hypothalamus-pituitary-adrenal (HPA) axis function can be drawn; in these cases, a stimulation test is required. Aim of this study was to develop an integrated model for the prediction of CAI when morning cortisol is in the grey zone, here defined as 40.0-160.0 μg/l.Methods: Overall, 119 pat...

ea0081p271 | Adrenal and Cardiovascular Endocrinology | ECE2022

The accuracy of adjusted unconventional indices for the assessment of selectivity and lateralization of adrenal vein sampling in the subtype diagnosis of primary aldosteronism

Bollati Martina , Parasiliti-Caprino Mirko , Bioletto Fabio , Ceccato Filippo , Lopez Chiara , Di Carlo Maria Chiara , Voltan Giacomo , Rossato Denis , Giraudo Giuseppe , Scaroni Carla , Ghigo Ezio , Maccario Mauro

Objective: This study aimed to evaluate the performance of simple and clinical/imaging-corrected unconventional indices in predicting the selectivity of adrenal vein sampling (AVS) and the lateralization of aldosterone hypersecretion in patients with primary aldosteronism (PA).Methods: Data of all consecutive patients with a proven diagnosis of PA who underwent AVS for subtype differentiation in two Italian referral centers were analyzed retrospectively....

ea0081p143 | Pituitary and Neuroendocrinology | ECE2022

Efficacy and safety of long-term high doses of cabergoline in prolactin secreting tumor

Bona Chiara , Prencipe Nunzia , Mazza Enrico , Maria Berton Alessandro , Bioletto Fabio , Varaldo Emanuele , Cuboni Daniela , Gottero Cristina , Gasco Valentina , Ghigo Ezio , Grottoli Silvia

Purpose: The aim of this study was to identify any predictive factors for need of high doses of cabergoline (CAB) in prolactinomas and to study any relationship between adverse events onset and CAB cumulative dose.Methods: Forty-two patients harboring resistant prolactinomas (High Dose group-HD; cabergoline dose ≥ 3.5 mg/week) were matched by gender, age and pituitary tumor diameter at diagnosis with subjects under standard doses (Standard Dose gro...

ea0081p397 | Pituitary and Neuroendocrinology | ECE2022

The cut-off limits of GH response to GHRH + arginine test related to body mass index for the diagnosis of adult GH deficiency: do we need to review our diagnostic criteria?

Cuboni Daniela , Varaldo Emanuele , Bioletto Fabio , Maria Berton Alessandro , Bona Chiara , Prencipe Nunzia , Ghigo Ezio , Maccario Mauro , Grottoli Silvia , Gasco Valentina

Introduction: The diagnosis of GH deficiency (GHD) in adults is based on a reduced GH response to provocative tests. The proportion of patients with low GH response to provocative tests increases with the number of other pituitary hormone deficiencies and several studies involving panhypopituitary patients have shown that under certain circumstances GH stimulation tests may be unnecessary to diagnose GHD.Objective: Aim of this study was to re-evaluate th...

ea0090p281 | Adrenal and Cardiovascular Endocrinology | ECE2023

The cardiometabolic risk in patients with non-functioning adrenal incidentaloma: an observational, retrospective and propensity score matched study

Parasiliti Caprino Mirko , Bioletto Fabio , Tomaiuolo Gabriella , Roux Anna , Lopez Chiara , Bollati Martina , Procopio Matteo , Arata Stefano , Ghigo Ezio , Arvat Emanuela , GIORDANO Roberta , Maccario Mauro

Introduction: Recent studies found an increased cardiometabolic risk in patients with Non-Functioning Adrenal Incidentaloma (NFAI), but all these data have low quality of evidence.Objective: To establish whether cardiometabolic risk and complications in NFAI patients can be associated to the presence of a non-secreting adrenal tumor, independently from potential confounding factors.Subjects and Methods: In this cross-sectional and ...

ea0090p285 | Adrenal and Cardiovascular Endocrinology | ECE2023

Predictive performance of aldosterone-to-renin ratio in the diagnosis of primary aldosteronism in patients with resistant hypertension

Bioletto Fabio , Lopez Chiara , Bollati Martina , Arata Stefano , Procopio Matteo , Ponzetto Federico , Beccuti Guglielmo , Mengozzi Giulio , Ghigo Ezio , Maccario Mauro , Parasiliti Caprino Mirko

Background: The systematic use of confirmatory tests in the diagnosis of primary aldosteronism (PA) increases costs, risks and complexity to the diagnostic work-up. In light of this, some authors proposed aldosterone-to-renin (ARR) cut-offs and/or integrated flow-charts to avoid this step. Patients with resistant hypertension (RH), however, are characterized by a dysregulated renin-angiotensin-aldosterone system, even in the absence of PA. Thus, it is unclear whether those str...

ea0090p709 | Pituitary and Neuroendocrinology | ECE2023

Adrenocortical, somatotropic and antidiuretic response to nasal glucagon in healthy subjects

Varaldo Emanuele , Bioletto Fabio , Cuboni Daniela , Prencipe Nunzia , Bona Chiara , Barale Marco , Ghigo Ezio , Grottoli Silvia , Maria Berton Alessandro , Gasco Valentina

Rationale: In the diagnosis of hypopituitarism, the glucagon stimulation test allows for the simultaneous and safe evaluation of the somatotropic and corticotropic axes; recent data have highlighted a stimulating action also on the neurohypophyseal secretion of arginine-vasopressin. This procedure involves the intramuscular or subcutaneous administration of 1-1.5 mg of glucagon based on the patient’s weight (respectively less or more than 90 kg). Nowadays no data are avai...

ea0081rc13.7 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

An observational retrospective study on the association of urine metanephrine levels with cardiometabolic risk in patients with nonfunctioning adrenal incidentaloma

Di Carlo Maria Chiara , Parasiliti Caprino Mirko , Lopez Chiara , Bollati Martina , Bioletto Fabio , Sola Chiara , Ponzetto Federico , Gesmundo Iacopo , Settanni Fabio , Ghigo Ezio , Mengozzi Giulio , Maccario Mauro , GIORDANO Roberta

Background: Several studies argued that the cardiovascular evaluation of patients with nonfunctioning adrenal incidentaloma is of particular importance, even if a direct association seems difficult to underline.Objective: We aimed to evaluate the possibility of stratifying cardiometabolic risk through metanephrine levels in patients with incidentally discovered nonfunctioning adrenal adenoma.Design: In this retrospective cross-sect...

ea0081p9 | Adrenal and Cardiovascular Endocrinology | ECE2022

Development and internal validation of a predictive model for the estimation of pheochromocytoma recurrence risk after radical surgery

Lopez Chiara , Parasiliti Caprino Mirko , Bioletto Fabio , Bollati Martina , Maletta Francesca , Caputo Marina , Gasco Valentina , La Grotta Antonio , Limone Paolo , Borretta Giorgio , Volante Marco , Papotti Mauro , Terzolo Massimo , Morino Mario , Pasini Barbara , Veglio Franco , Ghigo Ezio , Arvat Emanuela , Maccario Mauro

Objective: Various features have been identified as predictors of relapse after complete resection of pheochromocytoma, but a comprehensive multivariable model for recurrence risk prediction is lacking. The aim of this study was to develop and internally validate an integrated predictive model for post-surgical recurrence of pheochromocytoma.Methods: The present research retrospectively enrolled 177 patients affected by pheochromocytoma and submitted to ...