Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc12.1 | Diabetes | ECE2007

Hypoglycemia and cerebral ATP synthesis in Type 1 Diabetes

Mandl Martina , Zbyn Stefan , Mlynarik Vladimir , Promintzer Miriam , Luger Anton , Krebs Michael , Anderwald Christian , Bischof Martin G.

The mechanisms responsible for the progressive failure of hypoglycemia counter-regulation in type-1 diabetes (T1DM) are poorly understood. Alterations of brain energy metabolism could influence glucose sensing by the brain and, thus contribute to hypoglycemia associated autonomic failure. Thus, we measured intraneuronal kinetics of total ATP-synthesis from PCr (kfor) in T1DM patients and effects of hypo/hyperglycemia on this brain energy metabolism. Healthy n...

ea0014p68 | (1) | ECE2007

Circulating retinol binding protein 4 and protein C inhibitor are not related to insulin resistance

Promintzer Miriam , Krebs Michael , Luger Anton , Bischof Martin Georg , Nowotny Peter , Binder Christoph , Esterbauer Harald , Anderwald Christian

Recent data suggest that circulating retinol binding protein-4 (RBP4) is involved in the pathogenesis of insulin resistance in rodents and humans. Moreover, protein C inhibitor (PCI) which specifically binds retinoic acid was found to be increased in myocardial infarction survivors who are also insulin-resistant.Therefore, we investigated the association of insulin resistance with plasma retinol binding factors (RBP4 and PCI active antigen) in nondiabeti...

ea0014p261 | (1) | ECE2007

Hepatic and brain metabolism in young adults with glycogen storage disease type 1

Mandl Martina , Weghuber Daniel , Krssak Martin , Roden Michael , Nowotny Peter , Brehm Atilla , Krebs Michael , Widhalm Kurt , Bischof Martin

Glycogen storage disease type 1 (GSD1) is a rare inherited defect of endogenous glucose production. While children present with severe hypoglycemia the propensity for hypoglycemia may decrease with age in these patients. It was the aim of this study to elucidate the mechanisms for milder hypoglycemia symptoms in grown up GSD1 patients. Four patients with GSD1 (BMI: 23.2±6.3 kg/m2, age: 21±3 yr) and four healthy controls matched for BMI (23.1±3.0 kg/m<...

ea0014p244 | (1) | ECE2007

Insulin resistance and insulin secretion in morbidly obese patients before and six months after bariatric surgery

Promintzer Miriam , Prager Gerhard , Stadler Marietta , Anderwald Christian , Mandl Martina , Manesch Soheila Shakeri , Nowotny Peter , Bischof Martin Georg , Ludvik Bernhard , Luger Anton , Krebs Michael

Recent case reports describe hyperinsulinemic hypoglycemia after gastric bypass. The aim of this study was the assessment of insulin resistance and insulin secretion in non-diabetic morbidly obese patients before and six months after bariatric surgery.In 8 non-diabetic morbidly obese patients (OB:6f/2 m, age:42±3a, BMI:47.29±2.2 kg/m2) and 6 controls (CON:4f/2 m, age:43±0a, BMI:23.8±0.5 kg/m2) we performed a freq...