Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc12.1 | Diabetes | ECE2007

Hypoglycemia and cerebral ATP synthesis in Type 1 Diabetes

Mandl Martina , Zbyn Stefan , Mlynarik Vladimir , Promintzer Miriam , Luger Anton , Krebs Michael , Anderwald Christian , Bischof Martin G.

The mechanisms responsible for the progressive failure of hypoglycemia counter-regulation in type-1 diabetes (T1DM) are poorly understood. Alterations of brain energy metabolism could influence glucose sensing by the brain and, thus contribute to hypoglycemia associated autonomic failure. Thus, we measured intraneuronal kinetics of total ATP-synthesis from PCr (kfor) in T1DM patients and effects of hypo/hyperglycemia on this brain energy metabolism. Healthy n...