Endocrine Abstracts

Background: Hyponatraemia is a frequent finding in medical inpatients, where a comprehensive evaluation is warranted to establish the underlying mechanism and guide further management. Whilst the role of confounding medications, syndrome of inappropriate anti-diuretic hormone (SIADH), adrenal insufficiency and polydipsia is well-established as causative factors in the development of hyponatremia, the link between hypothyroidism and hyponatremia is controversial in the medical ...

Background: Bone mass is low and fracture risk is higher in obese children. We wished to ascertain the relationships of obesity-related changes in hormones with skeletal microstructure.Method: Children aged 8–15 years matched by gender and pubertal stage were recruited into lean and obese groups (18 pairs). We used high resolution peripheral quantitative computed tomography (HRpQCT – resolution-82 μm) to assess three-dimensional cortical a...

Introduction: There is a rare but well documented association between thymic hyperplasia and Graves’ disease particularly in young patients. It is important to recognise this as patients presenting with an anterior mediastinal mass will often undergo extensive investigations to exclude an underlying lymphoproliferative disorder.Case study: A 19-year-old female with symptomatic Graves’ thyrotoxicosis (TSH <0.01 mU/l; FT4 46.8 pmol...