Searchable abstracts of presentations at key conferences in endocrinology

ea0081p206 | Thyroid | ECE2022

Discordance between fT4 and TSH concentrations during levothyroxine treatment

Jansen Heleen , Bult Marijn , Bisschop Peter H. , Boelen Anita , C Heijboer Annemieke , Hillebrand Jacquelien

Introduction: Physicians in our hospital notified the laboratory staff of a number of patients at the outpatient clinic with increased free T4 (fT4) concentrations without (complete) suppression of thyroid stimulating hormone (TSH). This phenomenon appeared to occur more frequently following implementation of a new automated fT4 immunoassay. The discordance between fT4 and TSH concentrations may be explained by analytical issues (not further explained here), incorrect referenc...

ea0081rc1.5 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Sex steroids regulate liver fat content and body fat distribution in both men and women: a study in transgender persons

Tebbens Marieke , Schutte Moya , Troelstra Marian , Bruinstroop Eveline , de Mutsert Renee , Nederveen Aart , den Heijer Martin , Bisschop Peter H.

Objective: Visceral adipose tissue (VAT) and liver fat content are associated with insulin resistance and cardiovascular disease and show clear sex differences. Our objective is to determine the effect of estradiol and testosterone on VAT and liver fat content in trans women (assigned male at birth, identify as female) and trans men (assigned female at birth, identify as male).Design: Open-label partly randomized intervention study in 8 trans women and 1...

ea0063p652 | Interdisciplinary Endocrinology 1 | ECE2019

Restoring the sleep disruption by blue light emitting screen use in adolescents: a randomized controlled trial

Meijden Wisse P van der , Stenvers Dirk Jan , Kerkhof Linda van , Nierop Lotte van , Steeg Harry van , Bisschop Peter H , Someren Eus J van , Kalsbeek Andries

Introduction: Adolescents spend much time using blue-light emitting screen devices such as smartphones, tablets and computers. Blue light affects the central circadian clock in the suprachiasmatic nucleus (SCN) as well as melatonin secretion by the pineal gland. Screen use in adolescents strongly associates with reduced sleep quality and sleep duration. However, there is a lack of intervention studies that reduce blue light exposure due to screen use in adolescents.<p clas...

ea0070aep595 | Pituitary and Neuroendocrinology | ECE2020

Gallium-68 -DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas

M. Boertien Tessel , Booij Jan , Majoie Charles BLM , Drent ML , Pereira Alberto M , Biermasz Nienke , Simsek Suat , Groote Veldman Ronald , Stokkel Marcel PM , Bisschop Peter H , Fliers Eric

Background: Clinically non-functioning pituitary macroadenomas (NFMA) have been reported to express various somatostatin receptor (SSTR) subtypes, but results are inconsistent across different studies. This may be related to limited sensitivity and specificity of techniques used to date, i.e. immunohistochemistry in surgical specimens and 111In-DTPA-octreotide scintigraphy (Octreoscan) in vivo. The aim of this study was to assess SSTR expression in NFMA <em...

ea0063gp153 | Cushing's | ECE2019

Evaluation of the corticotrophin-releasing-hormone test and the high dose dexamethasone suppression test in ACTH dependent Cushing’s syndrome: a 25-year prospective cohort study

Muller Dion R.P. , Gent-Houben Moniek C.F. , van Vessem-Timmermans Martine , Linthorst Gabor E. , Serlie Mireille J. , Siegelaar Sarah E. , Soeters Maarten R. , Hillebrand Jacquelien J. , Heijboer Annemieke C. , Fliers Eric , Bisschop Peter H. , Jan Stenvers Dirk

Introduction: In patients with ACTH-dependent hypercortisolism, the corticotropin-releasing-hormone (CRH) test and the high dose dexamethasone suppression test (HDDST) can be used to differentiate between pituitary ACTH production (CushingÂ’s disease) and ectopic ACTH production. The rationale is that a pituitary adenoma will show some response to CRH and ACTH whereas an ectopic source is less responsive to ACTH and CRH. However, there is discussion about the clinical util...

ea0070ep340 | Pituitary and Neuroendocrinology | ECE2020

The galant trial: a randomised placebo-controlled trial in patients with a gallium-68 dotatate pet positive, clinically non-functioning pituitary macroadenoma on the effect of lanreotide on tumour size

Boertien Tessel M. , Drent M.L. , Booij Jan , Majoie Charles B.L.M. , Stokkel Marcel P.M. , Hoogmoed Jantien , Pereira Alberto M , Biermasz Nienke , Simsek Suat , Veldman Ronald Groote , Tanck Michael W.T. , Fliers Eric , Bisschop Peter H.

Rationale: At present, there is no approved medical treatment for patients with clinically non-functioning pituitary adenoma. A number of open-label studies suggest that treatment with somatostatin analogues may prevent tumour progression in selected patients. In vivo assessment of somatostatin receptor status using 68Ga-DOTATATE PET could help to select patients responsive to treatment.Trial objective: To investigate the effect of the somatosta...

ea0081yi11 | Young Investigator Awards | ECE2022

Diagnosing pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1 in daily practice

Pieterman Carolina , Van Beek Dirk-Jan , Wessels Frank J , van de Ven Annenienke C , de Herder Wouter W , Dekkers Olaf M , Zandee Wouter T , Drent Madeline L , Bisschop Peter H , Havekes Bas , Borel Rinkes Inne HM , Vriens Menno R , Valk Gerlof D

Background: Pancreatic Neuroendocrine Tumors (PanNETs) are highly prevalent in Multiple Endocrine Neoplasia type 1 (MEN1) and one of the main causes of mortality. Conventional imaging is the mainstay of PanNET screening/surveillance in MEN1. This study aims to assess the diagnostic accuracy of conventional pancreatic imaging studies and to determine the added value of pancreatic fine needle aspirations (FNA) for the diagnosis of MEN1-related PanNETs.Meth...