Endocrine Abstracts

Somatotroph adenomas are characterized by growth hormone hypersecretion and cell proliferation. We have previously identified crosstalk between the cAMP pathway and the MAPKinases ERK1/2 cascade and shown the central place of the MAPKinases in the control of the pituitary function in GH4C1 somatolactotroph cell line.The spatio-temporal organization of the signalling partners governs signalling fidelity and encodes the specificity of biological responses....

Pituitary tumors are most usual intracranial tumors, displaying hormonal hyper-secretion with in some cases a sustained cell proliferation. The somatotroph adenomas are characterised by a GH hypersecretion. The current treatments are based on somatostatinergic or dopaminergic agonists. Unfortunately, there is steel 50% of patients, which remain insensitive to these treatments. The aim of our work is to find a pharmacological alternative to treat the patients resistant to the c...