Endocrine Abstracts

BackgroundPrader Willi syndrome (PWS) is a genetic disorder with a broad clinical expression. Severe hypotonia with feeding difficulties during early infancy and delayed motor development are very characteristic. At older ages, common motor features in the PWS phenotype include decreased muscle strength, deficiencies in motor coordination and sequencing, gait disturbances and dyspraxic manifestations, with no clear pathophysiological mechanism yet identi...