Searchable abstracts of presentations at key conferences in endocrinology

ea0088008 | Abstracts | BES2022

Glycemic control in patients diagnosed with renal cell carcinoma. A case series

Herdt C De , L Billion , Block C De

Background: Few cases have been described with a new-onset or worsening of a pre-existing diabetes mellitus in patients diagnosed with a renal cell carcinoma and amelioration of their diabetes following tumour resection.Methodology: This is a retrospective study (2003-2021) including adult cases who were diagnosed with a renal cell carcinoma, who underwent tumour resection and whom glycemic control was monitored. HbA1c was measured at 3 time intervals; 1...

ea0088019 | Abstracts | BES2022

A profound hypocalcaemia following parathyroidectomy. A case report

Herdt C De , E Philipse , D Ysebaert , Block C De

Background: Hungry bone syndrome is a relatively uncommon but serious complication in patients who underwent parathyroidectomy for primary hyperparathyroidism. The syndrome is described as a hypocalcaemia (corrected serum calcium<2.1 mmol/L) lasting longer than four days after parathyroidectomy in the presence of a normal or elevated parathyroid hormone (PTH). Treatment is challenging and guidelines are based on clinical experience. To restore calcium levels high doses of ...

ea0097013 | Section | BES2023

Acquired idiopathic isolated adrenocorticotropic hormone deficiency: a descriptive systematic review of a heterogeneous and underreported disease

Mieghem E Van , Block C De , Herdt C De

Purpose: Deficiency of the adrenocortical axis is, except for glucocorticoid-induced adrenal deficiency, most commonly associated with failure of multiple pituitary axes and is less common isolated. Isolated adrenocorticotropic hormone deficiency (IAD) has been first described by Steinberg et al. in 1954. Acquired idiopathic IAD is defined by a secondary adrenal insufficiency with otherwise normal pituitary function, absence of structural pituitary defects, no...

ea0097021 | Section | BES2023

A non-controlled Cushing disease treated with osilodrostat: A case report

L Depoorter , Block C De , Herdt C De

Introduction: Cushing disease (CD) is a rare pathology and associated with serious complications and an increased mortality (standardized mortality ratio 2.8) (1). The mortality risk is twice as high (standardized mortality ratio 5.7) if CD is biochemically not well controlled. Transsphenoidal tumor resection is the first line treatment. However, the need for second line treatment is high, as 5-50% of patients in remission after surgery relapse and consist of ...

ea0097027 | Section | BES2023

Two family members with partial hypopituitarism and gingival fibromatosis caused by a missense mutation in KCNQ1

A Sabbe , Block C De , F Eyskens , Rademaecker M De , Herdt C De

Background: Childhood growth hormone deficiency (GHD) is a clinically heterogeneous condition and may have a genetic basis. Association with abnormalities of eyes, ears, palate and other parts of the forebrain or familial occurrence of GHD suggest a genetic cause (1). The occurrence of childhood GHD in association with gingival fibromatosis led to the identification of two autosomal dominant KCNQ1 missense variants (Arg116Leu and Pro369Leu). KCNQ1 gene encodes...

ea0079011 | Abstracts | BES2021

A cross-sectional analysis of the association between testosterone and biopsy-proven non-alcoholic fatty liver disease in 134 obese men

Herdt C De , Block C De , A Verrijken , Dessel K Van , S Francque , L Van Gaal , E Dirinck

Background and aims: Low levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was investigated in obes...

ea0088011 | Abstracts | BES2022

Diagnosis and management of patients with primary hyperaldosteronism; a single-centre experience

L Billion , Herdt C De , E Philipse , O D'Archambeau , D Ysebaert , A Snoeckx , B Peeters , Block C De

Background: Primary hyperaldosteronism (PA) is a prevalent, but underreported syndrome. Diagnostic procedures and treatment options have been relatively constant since the development of the latest guideline of the Endocrine Society in 2016.Study objective: To clinically and biochemically describe subjects with PA who underwent a salt infusion test (SIT) or an adrenal venous sampling (AVS) in a tertiary hospital since 2009 and provide an overview of thei...