Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep828 | Pituitary and Neuroendocrinology | ECE2022

The third case report of pituitary apoplexy complicated by a subarachnoid hemorrhage and ventricular extension

De Herdt Carlien , Niels Kamerling , Block Christophe De

Introduction: Pituitary apoplexy is a rare endocrine emergency due to hemorrhage of the pituitary gland. The clinical presentation depends on the extent of bleeding and can deteriorate into a life-threatening condition if complicated by a subarachnoid hemorrhage, as previously described in 2 cases.Case Description: A 60-year-old woman presented herself at the emergency department because of confusion for several hours. Clinical examination revealed aniso...

ea0073aep11 | Adrenal and Cardiovascular Endocrinology | ECE2021

The role of estimated glucose disposal rate as a predictor of insulin resistance, NAFLD and major adverse cardiovascular events in type 1 diabetes mellitus

Mertens Jonathan , Block Christophe De , Dirinck Eveline , Francque Sven

Background and AimsPeople with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD) despite insulin therapy to treat hyperglycaemia. Insulin resistance may be a contributing factor to CVD. Insulin resistance is strongly associated with NAFLD, which is increasingly linked to CVD. The estimated glucose disposal rate (eGDR) correlates well with the euglycemic clamp, which is the gold standard to assess insulin resistance in T1D, but ...

ea0088010 | Abstracts | BES2022

The insulin sensitivity index derived from euglycemic clamps is correlated to liver fat content determined by magnetic resonance spectroscopy in type 1 diabetes*

Jonathan Mertens , Rie Braspenning , Floris Vanhevel , Maarten Spinhoven , Sven Francque , Block Christophe De

Background: Insulin resistance is proposed as a causative factor of non-alcoholic fatty liver disease (NAFLD) in the general population. Reports on NAFLD in type 1 diabetes (T1D) are increasing , but whether insulin resistance is linked to NAFLD in this population needs elucidation. Furthermore, people with T1D are an excellent model to investigate insulin resistance in relation to NAFLD without confounding by autologous insulin production.Aims and Metho...

ea0073aep157 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Lipid accumulation product can accurately rule out, but not rule in non-alcoholic fatty liver disease in type 1 diabetes

Mertens Jonathan , Dirinck Eveline , Vonghia Luisa , Francque Sven , Block Christophe De

IntroductionLipid accumulation product (LAP), an index based on waist circumference (WC) and serum triglyceride levels, is associated with the presence and severity of non-alcoholic fatty liver disease (NAFLD). However, its potential as a risk marker of NAFLD in subjects with type 1 diabetes (T1D) has not been studied yet.AimsThis study evaluated the ability of LAP to estimate the presence of NAFLD in adults ...

ea0073aep203 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Is there an association between sex steroids and biopsy-proven non-alcoholic fatty liver disease in obese men? A cross-sectional analysis of 134 men

Herdt Carlien De , Block Christophe De , Kristof Van Dessel , An Verrijken , Francque Sven , Dirinck Eveline

Background and aimsLow levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was...

ea0079015 | Abstracts | BES2021

Factors associated with early postpartum weight retention in women with gestational diabetes

Caro Minschart , Loran Snoeks , Toon Maes , Block Christophe De , Pottelbergh Inge Van , Nele Myngheer , Pascale Abrams , Wouter Vinck , Liesbeth Leuridan , Chantal Mathieu , Jaak Billen , Christophe Matthys , Babs Weyn , Annouschka Laenen , Annick Bogaerts , Katrien Benhalima

Aims: To identify factors associated with early postpartum weight retention (PPWR) in women with recent gestational diabetes mellitus (GDM).Methods: Multicentric prospective study in women with a recent history of GDM based on the IADPSG criteria at the oral glucose tolerance test (OGTT) 6-16 weeks postpartum. Data obtained from electronic medical records, self-administered questionnaires, clinical examination and blood sample collection were used for th...

ea0079016 | Abstracts | BES2021

Characteristics, pregnancy outcomes and tolerance of screening tests according to the preference of women for the method of GDM screening

Lore Raets , Marie Vandewinkel , Paul Van Crombrugge , Carolien Moyson , Johan Verhaeghe , Sofie Vandeginste , Hilde Verlaenen , Chris Vercammen , Toon Maes , Els Dufraimont , Block Christophe De , Yves Jacquemyn , Farah Mekahli , Katrien De Clippel , Den Bruel Annick Van , Anne Loccufier , Annouschka Laenen , Roland Devlieger , Chantal Mathieu , Katrien Benhalima

Aims: To compare the characteristics, pregnancy outcomes and tolerance of screening tests between women who prefer a two-step screening strategy with a glucose challenge test (GCT), women who prefer an one-step screening strategy with an oral glucose tolerance test (OGTT) and women without clear preference for screening method for gestational diabetes mellitus (GDM). Methods: 1803 women from a Belgian multi-centric prospective cohort study (BEDIP-N study...