ea0037oc1.3 | Adrenal 1 | ECE2015
Hahner Stefanie
, Heinze Britta
, Herrmann Ken
, Buck Andreas K
, Blumel Christina
, Hanscheid Heribert
, Brumberg Joachim
, Michelmann David
, Nannen Lukas
, Ries Martin
, Fassnacht Martin
, Allolio Bruno
, Schirbel Andreas
Background: We have recently introduced [123/131I]iodometomidate (IMTO) which selectively binds to the adrenocortical enzymes aldosterone synthase and 11ß-hydroxylase as SPECT tracer. IMTO has been proven to be useful for molecular adrenal imaging and radiotherapy in adrenal cancer (ACC). As IMTO is rapidly inactivated by endogenous esterases which may impair target tissue to background activity and therapeutic efficacy, >50 new IMTO derivatives have been d...