Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep592 | Obesity and cardiovascular endocrinology | ECE2015

Relationship between thyroid hormone status and concomitant medication in hyperlipidaemic patients with statin induced adverse effects

Berta Eszter , Zsiros Noemi , Nagy Endre , Paragh Gyorgy , Bodor Miklos

Statins are effective treatment for the prevention of cardiovascular diseases and used extensively worldwide. However, adverse effects induced by statins are the major barrier of maximalising cardiovascular risk reduction. Hypothyroidism and administration of drugs metabolised on the same cytochrome P450 (CYPP450) pathways where statin biotransformation occurs represent a significant risk factor for statin induced adverse effects including myopathy. Simvastatin, atorvastatin a...

ea0063p719 | Pituitary and Neuroendocrinology 2 | ECE2019

Control of hyperglycemia in a young male patient with gigantism during transition: a case report

Berta Eszter , Lengyel Inez Mercedesz , Halmi Sandor , Puskas Istvan , Felszeghy Enikő , Balogh Zoltan , Nagy Endre V , Bodor Miklos

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...

ea0037gp.27.08 | Thyroid – hyperthyroidism and treatment | ECE2015

There is a detectable immune activity in the orbits of all patients diagnosed with Graves' disease regardless of later development of Graves' orbitopathy

Berta Eszter , Ujhelyi Bernadett , Szabados Lajos , Galuska Laszlo , Erdei Annamaria , Gazdag Annamaria , Halmi Sandor , Nagy Endre , Bodor Miklos

Graves’ orbitopathy (GO) is a common complication of Graves’ disease (GD) which is often responding poorly to therapy. GO may develop before or together with, or during the course of GD. In an individual patient, the development of GO cannot be predicted. We assumed that orbital autoimmune activity is predictable using orbital 99mTc-labelled diethylenetriamine pentaacetic acid (99mTc-DTPA) SPECT. We aimed to determine whether any orbital autoimmune activity can be id...

ea0056p1095 | Thyroid (non-cancer) | ECE2018

Serum chemerin and other dyslipidemia markers in patients with autoimmune thyroiditis

Berta Eszter , Harangi Mariann , Varga Viktoria E , Lorincz Hajnalka , Seres Ildiko , Halmi Sandor , Nagy Endre V , Paragh Gyorgy , Bodor Miklos

Aim: Chemerin, a recently discovered adipokine produced by the adipose tissue and liver, along with other atherosclerosis markers, was associated lately with metabolic syndrome and acts as chemoattractant for immune cells may also regulate immune cell properties. Autoimmune Hashimoto’s thyroiditis even with sTSH levels corrected to be within the normal range values may be accompanied by dyslipidemia presenting increased total-C, TG, LDL-C, and Lp(a), all of which are pote...

ea0073aep410 | General Endocrinology | ECE2021

Successful treatment of nesidioblastosis during the time of pandemic: A case report

Sándor Halmi , Berta Eszter , Lengyel Inez , Toth Judit , Kanyari Zsolt , Hutkai David , Nagy V Endre , Bodor Miklos

IntroductionIn the background of persistent hyperinsulinemic hypoglycemia the insulinomas of the pancreatic beta cells may be present, but in some rare cases we fail to identify a well-defined lesion and the insulin hypersecretion is caused by nesidioblastosis, a diffuse proliferation of the pancreatic islet cells. However, the localization of the lesion is necessary for proper treatment, in certain cases finding the insulinoma is difficult and can only ...

ea0084ps2-07-64 | Graves’ Disease 1 | ETA2022

The effect of glucocorticoids on hyaluronan production of orbital fibroblasts

Galgoczi Erika , Katko Monika , Erdei Annamaria , Bodor Miklos , Ujhelyi Bernadett , Steiber Zita , Gyory Ferenc , V. Nagy Endre

Objectives: Glucocorticoids (GCs) are the first line therapy in moderate to severe, active thyroid eye disease (TED). While their beneficial immunosuppressive effects are well known, direct connective tissue effects are less characterized. The accumulation of extracellular matrix component hyaluronan (HA) and increased proliferation rate of fibroblasts are hallmarks connective tissue changes in TED. We examined the effect of methylprednisolone (MP), prednisolone (P), hydrocort...

ea0081ep400 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Association of chemerin and serum advanced glycation end products in patients with autoimmune thyroiditis

Bak-Csiha Sara , Halmi Sandor , Hutkai David , Molnar Istvan , Katko Monika , Lőrincz Hajnalka , Harangi Mariann , Paragh Gyorgy , Nagy Endre , Bodor Miklos , Eszter Berta

Background: Hypothyroidism due to autoimmune thyroiditis leads to atherogenic lipid profile and metabolic changes. The formation of advanced glycation end products (AGEs) increases with hyperglycemia, hyperlipidemia and oxidative stress. Degradation of AGEs after AGEs-receptor 1-mediated intracellular uptake and renal clearance of soluble AGEs generated by certain cells like macrophages play a crucial role in the decrement of circulating AGEs level. Chemerin is an adipokine pr...