Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep115 | Calcium and Bone | ECE2021

Transient hypocalcaemia and definitive hypoparathyroidism after total thyroidectomy in Graves’ disease

Bruno Bouça , Amaral Sara , Vasques Miguel , Monteiro Nuno , Crespo Ana , José Coutinho , Tavares Paula , Bogalho Paula , José Silva-Nunes

IntroductionHypocalcaemia is a complication of total thyroidectomy (TT) and may be more frequent in patients with Graves’ disease. The reason for this increased risk is unclear and its occurrence has been associated with: ophthalmopathy severity, preoperative calcaemia and reimplantation of parathyroid glands.ObjectivesTo evaluate the risk factors for transient hypocalcaemia (TH) and definitive hypoparat...

ea0049ep10 | Adrenal cortex (to include Cushing's) | ECE2017

Addison’s disease presenting as severe hypoglycaemia and cachexia

Martins Ana Claudia , Bogalho Paula , Agapito Ana

Addison’s disease (AD), also known as primary adrenal insufficiency, is caused by destruction or dysfunction of the adrenal cortex, resulting in hypocortisolism. The usual clinical features of chronic AD are non-specific and include fatigue, nausea, vomiting and hyperpigmentation. We describe the case of a 58-year-old African black male with AD presenting with recurring severe hypoglycaemia. The patient was admitted several times to the emergency department with hypoglyca...

ea0049ep253 | Calcium & Vitamin D metabolism | ECE2017

Pseudohypoparathyroidism type Ib: a case of chronic severe hypocalcaemia and seizures diagnosed in adulthood

Claudia Ana , Martins , Bogalho Paula , Agapito Ana

Pseudohypoparathyroidism (PHP) is a rare group of genetic disorders characterised by end-organ resistance to parathyroid hormone (PTH). We describe the case of a 34-year-old Caucasian female with severe hypocalcaemia presenting with a first generalised seizure. Her medical history was significant for bilateral cataract. She had three healthy children, and no family history of note. On examination, she had positive Chvostek’s sign. Biochemical analysis showed serum calcium...

ea0081p380 | Endocrine-Related Cancer | ECE2022

Hormonal therapy in breast cancer patients and malignancy risk of thyroid nodules

Abegao Matias Alexandra , Bouca Bruno , Sabino Teresa , Bogalho Paula , Silva-Nunes Jose

Introduction: The bidirectional relationship of risk between breast cancer (BC) and thyroid cancer (TC) has been debated. Estrogens are proposed as agents implicated in the risk of developing TC promoting thyroid tumorigenesis. Therapies that reduce the effect of estrogens on their receptors in cancer cells are widely used.Objective: To correlate the use of hormonal therapy in BC with the prevalence of TC.Material and Methods: We p...

ea0081p675 | Pituitary and Neuroendocrinology | ECE2022

Central diabetes insipidus following immunization with BNT162b2 mRNA Covid-19 vaccine

Bouca Bruno , Roldao Marisa , Bogalho Paula , Cerqueira Luis , Silva-Nunes Jose

Introduction: The endocrine complications of COVID-19 remain largely unknown. Cases of central diabetes insipidus (CDI) have been reported after COVID-19, with hypophysitis being the most likely cause. COVID-19 vaccines potential adverse effects may mimetize some of these complications. We present a case of a woman who developed CDI one week after the 2 nd dose of BNT162b2 mRNA COVID-19 vaccine.Case Report: Female patient, 37 years old, with rheumatoid a...

ea0081p185 | Reproductive and Developmental Endocrinology | ECE2022

Management of 46, XY 17 alpha-hydroxylase deficiency: a case report

Bouca Bruno , Cascao Mariana , Fiuza Pedro , Amaral Sara , Bogalho Paula , Silva-Nunes Jose

Introduction: 17 alpha-hydroxylase deficiency (17OHD) is a rare autosomal recessive disease caused by mutations in the CYP17A gene, representing 1% of cases of Congenital Adrenal Hyperplasia (CAH). The accumulation of mineralocorticoids and the glucocorticoid effect of corticosterone induce high blood pressure (HBP) and hypokalemia.Clinical Case: A 44 year-old female reporting HBP since the age of 20 years and without chronic medication, presented at the...

ea0073pep2.1 | Presented ePosters 2: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

MODY 5: a rare cause of diabetes and chronic kidney disease – a report of 10 cases

Amaral Sara , Cláudia Martins Ana , Palha Ana , Bogalho Paula , Agapito Ana , Silva-Nunes Jose

IntroductionMaturity Onset Diabetes of the Young (MODY) affects 1–2% of diabetic patients. Subtype 5 (HNF1β mutation) is rare (~1% of all MODY subtypes) and extra-pancreatic manifestations are often present (chronic kidney disease (CKD), liver disease and/or genitourinary malformations).AimTo report and review confirmed MODY 5 cases in an Endocrinology Department.Meth...

ea0049ep181 | Endocrine tumours and neoplasia | ECE2017

Insulinoma – clinical features and outcome of patients diagnosed at a central hospital

Prokop Joanna , Martins Ana Claudia , Neves Carolina , Sabino Teresa , Bogalho Paula , Nunes Jose Silva , Fonseca Fernando , Agapito Ana

Insulinoma, a rare neuroendocrine tumor (NET), is benign in more than 90% of cases. We present a review of patients diagnosed with insulinoma at our Department.Methods: Retrospective review of clinical records of patients diagnosed with insulinoma between 2011 and 2016.Results: Six female patients were diagnosed with insulinoma (age at presentation 30–66, follow-up: 0.25–3.25 years). Episodes of sweating, palpitations, tr...

ea0049ep599 | Diabetes therapy | ECE2017

Pancreas transplantation: experience in a central hospital

Martins Ana Claudia , Vasques Miguel , Bogalho Paula , Aires Ines , Ferreira Anibal , Remedio Francisco , Paulino Jorge , Nolasco Fernando , Martins Americo , Agapito Ana

Introduction: Pancreas transplantation is an established treatment for selected patients with type 1 diabetes mellitus (T1DM) and severe chronic kidney disease (CKD), reducing mortality and morbidity.Methods: We retrospectively reviewed the cases of pancreas transplantation performed at our centre from 1-January-2011 to 30-June-2016.Results: In this period, 53 transplants were performed: 48 simultaneous pancreas-kidney transplants ...

ea0070aep912 | Thyroid | ECE2020

Thyroid arterial embolization for refractory amiodarone-induced thyrotoxicosis in a patient with congenital heart disease

Bouça Bruno , Cláudia Martins Ana , Bogalho Paula , de Sousa Lídia , Bilhim Tiago , Veloso Gomes Filipe , Coimbra Élia , Agapito Ana

Introduction: Amiodarone-induced thyrotoxicosis (AIT) in patients with congenital heart disease (CHD) has an estimated cumulative incidence of 13–21%, and prompt reversal to euthyroidism is crucial in these patients. We present a case of refractory AIT in a patient with CHD who was treated with thyroid arterial embolization (TAE).Clinical case: A 34-year-old male with complex cyanotic CHD (great vessels transposition, interventricular communication...