Searchable abstracts of presentations at key conferences in endocrinology

ea0035p391 | Diabetes (epidemiology, pathophysiology) | ECE2014

Vitamin D, insulin dependency and BMI in type 1 diabetes

Bogdanou Dimitra , Penna-Martinez Marissa , Shoghi Firouzeh , Badenhoop Klaus

Type 1 diabetes mellitus (T1D) is caused by a process of altered humoral and cellular immunity, resulting in the destruction of insulin-producing cells. VD(25(OH)D3) insufficiency is implied as risk factor for T1D, while VD substitution in infantry is associated with a reduced T1D incidence. In T1D daily insulin injection is required for a stable glucose homeostasis and insulin demand rises by a higher Body Mass Index (BMI). Today there are no studies investigating ...

ea0035p523 | Endocrine tumours and neoplasia | ECE2014

A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling

Bogdanou Dimitra , Meyer Gesine , Stucker Anja-Undine , Hansmann Martin-Leo , Thalhammer Axel , Bojunga Jorg

Background: Multiple diagnostic modalities may be needed to establish the source of excessive androgen production in women. The detection of testosterone-producing ovarian tumors by imaging techniques can be difficult because of their in same cases small size and radiological structure.Case report: We describe a 55-year-old postmenopausal woman presenting with progressive severe virilization (Ferriman Gallwey-Score: 23–26), increased hair growth, ma...

ea0041gp93 | Diabetes (2) | ECE2016

High dose vitamin D treatment regulates the gene expression pattern in T helper cells of type 1 diabetes patients

Penna-Martinez Marissa , Hess Helen , Doring Claudia , Nejatian Nojan , Bogdanou Dimitra , Shoghi Firouzeh , Hansmann Martin-Leo , Badenhoop Klaus

Dysregulated T helper cells and vitamin D (VD) deficiency are important factors in the pathogenesis of Type 1 diabetes mellitus (T1D). Therefore, we investigated the immune effects of high dose VD-treatment on gene expression (GE) pattern in T helper cells (Th) before and after VD-therapy in patients with T1D.Methods: Seven T1D patients with 25(OH)D3 levels below 20 ng/ml received 3 months 4000 IU/d Vigantol oil. The 25(OH)D3 plasma...