Searchable abstracts of presentations at key conferences in endocrinology

ea0067o12 | Oral Presentations | EYES2019

Brain energy metabolism in an animal model of the co-occurrence of depression and hypothyroidism

Głombik Katarzyna , Detka Jan , Kurek Anna , Budziszewska Bogusława

Objective: The association between thyroid function and mood disorders has long been recognized but little is known about the mechanisms underlying this relationship. Thyroid dysfunction often leads to the development of mental diseases and in patients with affective disorders, 1–4% suffers from hypothyroidism and 4–40% show signs of subclinical hypothyroidism. The aim of the present study was to assess the effects of hypothyroidism on metabolic processes in the brai...

ea0070aep599 | Pituitary and Neuroendocrinology | ECE2020

Midparental height is an important predictive parameter in a late diagnosis of acromegaly and gigantism in adults. Single centre, pilot study

Bogusławska Anna , Gilis-Januszewska Aleksandra , Godlewska Magdalena , Olszewska Marta , Hubalewska-Dydejczyk Alicja , Starzyk Jerzy

Introduction: Acromegaly is a rare disorder caused by excessive growth hormone production. Common clinical manifestations are visual changes as well as serious systemic complications. In childhood and adolescence, excessive growth hormone production leads to abnormal tall stature. To date, only a few studies have been published focusing on analysing the growth of patients with acromegaly, in particular regarding the growth of their parents and siblings. A&#...

ea0073aep472 | Pituitary and Neuroendocrinology | ECE2021

Age and sex differences among patients with acromegaly

Anna Boguslawska , Gilis-Januszewska Aleksandra , Godlewska Magdalena , Nowak Andrzej , Starzyk Jerzy , Hubalewska-Dydejczyk Alicja

IntroductionAcromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary neuroendocrine tumors (PitNETs). This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of age at the onset of symptoms and sex on clinical features, comorbidities, biochemical status at the diagnosis, a...

ea0081p690 | Pituitary and Neuroendocrinology | ECE2022

Clinical characteristics at diagnosis and diagnostic delay among newly-diagnosed patients with acromegaly- single-center, pilot study

Godlewska Magdalena , Bogusławska Anna , Kluczyński Łukasz , Rzepka Ewelina , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Introduction: Diagnostic delay remains significant among the patients with acromegaly, even though the disease awareness has improved over the years.Aim: The aim was to investigate the diagnostic delay and symptoms present at diagnosis of acromegaly among the newly-diagnosed patients.Material and methods: 72 consecutive patients diagnosed with acromegaly between 01.2014 and 12.2021 were evaluated. Division into groups based on: gen...

ea0081p693 | Pituitary and Neuroendocrinology | ECE2022

Multimodal treatment including temozolomide (TMZ) and pasireotide for aggressive, giant silent corticotroph PiTNET in a young patient

Bogusławska Anna , Kluczyński Łukasz , Godlewska Magdalena , Rzepka Ewelina , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Silent corticotroph pituitary neuroendocrine tumours (PiTNETs) are a subtype of nonfunctioning PiTNETs, that present positive immunostaining for adrenocorticotropin (ACTH) and/or show the expression of the transcription factor T-PIT without clinical signs of hypercortisolemia. They constitute 20% of all corticotroph PitNETs and manifest in most cases as macroadenoma with suprasellar extension and a higher tendency to apoplexy. We present a 33-year-old male with aggressive cour...

ea0081ep701 | Pituitary and Neuroendocrinology | ECE2022

Age at the diagnosis or age at the onset of symptoms- which should be taken into consideration in patients with early-onset acromegaly- pilot study

Godlewska Magdalena , Bogusławska Anna , Kluczyński Łukasz , Rzepka Ewelina , Hubalewska-Dydejczyk Alicja , Gilis-Januszewska Aleksandra

Introduction: The group of young adults with acromegaly, despite initial reports about their aggressive course of disease, has not been thoroughly characterized. Aim: Our aim was to investigate the differences between the patients with early-onset acromegaly and with onset in older age. Material and methods: Consecutive patients diagnosed with acromegaly between 01.2014 and 12.2021 were included in this retrospective study, approve...

ea0081ep727 | Pituitary and Neuroendocrinology | ECE2022

Challenging management of giant prolactinomas in men: from efficient small dose of cabergoline to SSA, neurosurgery and Temozolomide

Gilis-Januszewska Aleksandra , Bogusławska Anna , Godlewska Magdalena , Kluczyński Łukasz , Hubalewska-Dydejczyk Alicja

Giant prolactinomas are very rare and constitute 2-3% of all lactotroph PitNETs with male preponderance. We present a case series of five male patients with giant prolactinomas with various clinical presentation. Case 1: A 66-year-old male hospitalized due to left peripheral facial palsy. In computer tomography (CT) pituitary mass (41 x 43 x 64 mm) invading cavernous/sphenoid sinuses/carotid arteries/optic chiasm was visualized. Bitemporal hemianopia/hea...

ea0073aep538 | Pituitary and Neuroendocrinology | ECE2021

Silent somatotroph giant pituitary adenoma with the first manifestation at the age of 15 with a 16-year follow up- case report

Godlewska Magdalena , Gilis-Januszewska Aleksandra , Anna Boguslawska , Przybylik-Mazurek Elwira , Zielinski Grzegorz , Hubalewska-Dydejczyk Alicja , Jurecka-Lubieniecka Beata

BackgroundSilent somatotroph pituitary tumours are very rare, representing only 2-4% of all pituitary tumours in surgical series. Little is known about the course of the disease and efficacy of possible treatment modalities.Presentation of the caseA male, born in 1990, was first admitted to the hospital at the age of 15, due to sudden ptosis of the right eye and headaches, present for 1 year before the diagno...

ea0081p409 | Pituitary and Neuroendocrinology | ECE2022

Differences of clinical characteristics and treatment of sporadic and MEN-1 related insulinomas

Opalinska Marta , Gilis-Januszewska Aleksandra , Morawiec-Sławek Karolina , Rzepka Ewelina , Bogusławska Anna , Sowa Staszczak Anna , Hubalewska-Dydejczyk Alicja

Background: Although in most cases insulinomas are small and benign tumors, in about 4% they are malignant, mainly in course of inherited syndromes like MEN1, tubular sclerosis or neurofibromatosis type 1. While in case of benign tumors surgery is usually curative, the metastatic form brings difficulties in managing due to dissemination and the risk of recurring, life-threating, severe hypoglycemias. To elucidate the clinical differences between sporadic and MEN-1 linked insul...

ea0073aep399 | Endocrine-Related Cancer | ECE2021

Heterogeneity of the clinical presentation of the MEN1 LRG_509t1 c.781C > T (p.Leu261Phe) variant within a three-generation family

Gilis-Januszewska Aleksandra , Anna Boguslawska , Godlewska Magdalena , Hasse-Lazar Kornelia , Jurecka-Lubieniecka Beata , Jarzab Barbara , Sowa-Staszczak Anna , Skalniak Anna , Hubalewska-Dydejczyk Alicja

BackgroundMultiple neuroendocrine neoplasia type 1 is a rare, heterogeneous genetic disorder with an autosomal dominant inheritance, predisposing to benign and malignant tumors. The phenotype of MEN1 syndrome varies between patients in terms of tumor localisation, age of onset and clinical aggressiveness, even between affected members of the same family. We report a heterogenic phenotype of the MEN1 variant c.[781C > T] (LRG_509t1) previously reporte...