Endocrine Abstracts

Introduction: Hypertriglyceridemia is an established complication associated with some parenterally fed patients. In healthy individual, lipid particles are hydrolyzed to release fatty acids via the action of lipoprotien lipase (LPL) which used eventually for energy or stored in adipose tissue. In stressed patient, the activity of LPL is decreased. We present a 16-year-old girl, who is a known case of acute myeloid leukemia on chemotherapy, was admitted to the hospital with se...

Carcinoid tumours are low grade neoplasms usually arising from neuroendocrine cells of the bronchial and gastrointestinal tracts. Carcinoid tumours metastasise in 50–75% of patients, most commonly to lymph nodes, liver, and bones, but intra-orbital metastases have only rarely been reported. Here, we describe a patient who presented with an intra-orbital neuroendocrine tumour which was successfully treated with surgery and radiotherapy. A 70-year-old female patient present...

Introduction: Maturity-onset diabetes of the young (MODY) is a genetically and clinically heterogeneous type of diabetes mellitus, characterized by early onset (often before 25 years of age) and absence of pancreatic autoimmunity markers.Case: We report a 20 years old female diagnosed with type 1 diabetes at age 18, with positive glutamic acid decarboxylase antibodies and low C peptide level. She had no history of diabetic ketoacidosis or hypoglycemia. H...

Graves disease is an autoimmune disorder of the thyroid gland. It is a very rare condition that a Graves patient presents with spontaneous hypothyroidism. Hypothyroidism during the course of Graves’ disease occurs commonly due to radio-iodine (RAI) therapy or thyroidectomy. It may also develop after anti-thyroid drug (ATD) treatment. We present a case of 44 years old Emarati male heavy smoker diagnosed with graves’ disease after thyrotoxic manifestations, associated ...

Adrenal lesions are commonly detected incidentally during cross-sectional imaging examinations, and the majority are benign adrenal adenomas. A 52 year old gentleman with a history of hypertension and paroxysmal atrial fibrillation was referred to our service following a fall in which he fractured several ribs. Subsequent abdominal CT revealed an incidental finding of bilateral adrenal masses, reported as approximately 5 cm and 4 cm on the right and left side respectively with...

BackgroundTSHomas are a rare cause of hyperthyroidism, and account for 0.5 to 3% of pituitary tumours. Incidence=0.15 per million per year. Prevalence=1 per million. Our limited experience of this condition can result in diagnostic and treatment challenges. Here we describe a case treated surgically lead to successful outcomesCase35 years old female referred to our service with secondary amenorrhea for the la...

Introduction: pituitary duplication is a rare congenital malformation. It has been mainly reported in the pediatric and neonatal population with few reported cases in the adult population. In this case we will be discussing the presentation of an adult female patient with pituitary stalk duplication and empty Sella causing hyponatremia.Case Presentation: A 46-year-old female presented with severe euvolemic hyponatremia. ...

We report a new diagnosis of a pituitary TSH-oma together with a metastaticneuroendocrine tumour. A 61 year old man presented with a 3-year history of diarrhoea. His past medical history includes paroxysmal atrial fibrillation, for which he has had an ablation in the past. He takes no regular medications. Initial investigations were suggestive of hyperthyroidism in the context of unusual thyroid function test results (elevated freeT4 and freeT3 with elevated TSH). A pituitary ...

Von Hippel-Lindau (VHL) disease is an inherited tumour syndrome, caused by a mutation in the VHL tumour suppressor gene encoding the VHL protein. Patients are prone to cysts and neuroendocrine tumours in the pancreas and other benign and malignant neoplasms. Pancreatic cysts occur in approximately 70% of VHL patients. We describe two cases of VHL disease with extensive multi-cystic changes affecting the whole pancreas, both patients had deletions of exon 2–3 of the VHL ge...

A 28-year-old woman presents with a one-year history of marked weight gain of 18 kg, increasing hirsutism and night sweats. Clinically, hyperandrogenism and Cushing’s syndrome were suspected. A diagnosis of Polycystic ovarian syndrome was made based on Rotterdam criteria and Metformin was initiated. Initial testing for Cushing’s syndrome demonstrated a high 24 h urinary free cortisol (306 nmol/l) with incomplete cortisol suppression on an overnight dexamethaso...