Searchable abstracts of presentations at key conferences in endocrinology

ea0022p257 | Developmental endocrinology | ECE2010

Mineralocorticoid pathway in newborns: evidence for a physiological renal aldosterone unresponsiveness

Martinerie Laetitia , Viengchareun Say , Boileau Pascal , Lombes Marc

Aldosterone is the main steroid hormone controlling sodium homeostasis in human. During the neonatal period, full term newborns and more specifically premature infants, are subjected to an impaired renal capacity to reabsorb sodium, responsible for sodium loss and failure to thrive which could be linked to a renal aldosterone unresponsiveness at birth. A clinical prospective study on 50 newborns and their mothers, revealed high aldosterone and renin levels in umbilical blood s...