Searchable abstracts of presentations at key conferences in endocrinology

ea0013p327 | Thyroid | SFEBES2007

RET proto-oncogene exon 11 germline mutations in patients with medullary thyroid carcinoma

Petakov Milan , Nikolic Jelena , Katarina Mirkovic , Jadranka Antic , Jovana Vignjevic , Bojana Beleslin-Cokic , Tatjana Isailovic , Sanja Ognjanovic , Djuro Macut , Svetozar Damjanovic

Several RET proto-oncogene germline mutations with dominant inheritance, predispose to hereditary medullary thyroid carcinoma (MTC), and whether the MTC is sporadic or hereditary should be determined by a direct analysis of the RET proto-oncogene. 85% of MEN IIA patients and 30% of patients with familial medullary thyroid carcinoma have mutations at codon 634 (exon 11). In 88 consecutive patients with MTC, the characterization of RET mutations in exon 11 had been done by PCR w...