Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep168 | Endocrine tumours and neoplasia | ECE2017

Hyperinsulinemic hypoglycemia in a 71-year-old patient with a suspected case of β-cells hyperplasia of pancreatic body and tail- case report

Pancic Jelena Malinovic , Caric Bojana , Popovic Bojana

B-pancreatic cells are programmed to react to plasma glucose level with insulin secretion. Insulin secretion is precisely regulated and in the physiological conditions fasting glucose levels are maintained in the range 3.5–5.5 mmol/l. In hyperinsulinemic hypoglycemia, a disorder of the regulation of insulin secretion, insulin secretion continues at low concentrations of plasma glucose. In adults hyperinsulinemic hypoglycemia is the cause of 0.5 to 5.0% of hypoglicaemias a...

ea0037eyes1.4 | Sex, drugs and rocking hormones | ECE2015

Hypothalamo-pituitary-adrenal axis response and adaptation to repeated physical stress in professional athletes

Popovic Bojana , Popovic Dejana , Macut Djuro , Antic Ivana Bozic , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Ilic Dusan , Antic Jadranka , Petakov Milan , Damjanovic Svetozar

Activation of hypothalamo-pituitary-adrenal (HPA) axis is a common feature of endocrine responses to stress, with cortisol secretion as an end product of this activation. Acute rise in cortisol level during stress is of utmost importance for metabolic adjustments, immune system adaptations, cardiovascular responses and muscle tissue remodeling. But since chronic hypercortisolism has many deleterious effects, scientific interest has started focusing around different biological ...

ea0032p274 | Clinical case reports - Thyroid / Others | ECE2013

Paraganglioma, germline nonsense mutation in succinate dehydrogenase B gene (R27X) and response to sunitinib

Elezovic Valentina , Petakov Milan , Ognjanovic Sanja , Macut Djuro , Isailovic Tatjana , Ilic Bojana , Popovic Bojana , Antic Ivana Bozic , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

A 36-years-old male with mild hypertension was diagnosed with pseudocystic tumor (67 mm) in pancreatic region and liver metastasis in April 2010. One month later, the extirpation of retroperitoneal mass and metastasis was performed in local medical centre. Pathohistological diagnosis was metastatic paraganglioma (Ki67, 3.5%). In June 2010, he was transferred to our Institution, and (131) I-metaiodobenzylguanidine (MIBG) scintigraphy was negative. However ((18) F) fluorodeoxygl...

ea0014p173 | (1) | ECE2007

Novel mutations in genes encoding succinate dehydrogenase complex subunits B (SDHB) and von Hippel-Lindau protein (VHL) in patients with nonsyndromic pheochromocytoma

Vignjevic Jovana , Nikolic Jelena , Isailovic Tatjana , Mirkovic Katarina , Petakov Milan , Antic Jadranka , Macut Djuro , Beleslin-Cokic Bojana , Popovic Bojana , Bozic Ivana , Ognjanovic Sanja , Damjanovic Svetozar

Background: Several susceptibility genes have been found to be associated with development of pheochromocytoma (PHEO): RET, VHL, SDHB and SDHD. We investigate the frequency of germ-line mutations in SDHB and VHL genes in patients with apparently sporadic PHEO.Material and methods: Fifty patients (38 women, mean age 42) with apparently sporadic adrenal and extra-adrenal PHEO were screened. DNA was extracted from whole blood and from paraffin embedded tumo...

ea0081ep615 | Endocrine-Related Cancer | ECE2022

Frequency of CYP1B1 gene polymorphism in obese and non-obese women with hormone-dependent endometrial cancer

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

ea0090ep618 | Endocrine-related Cancer | ECE2023

Merkel cell carcinoma, experience of a single center

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

ea0070aep365 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The acute effects of short-term insulin therapy on the secretory ability of beta cells in patients with diabetes mellitus type 2, after the secondary failure of the oral therapy

Grbic Aleksandra , Malesevic Gabrijela , Soldat-Stankovic Valentina , Caric Bojana , Popovic-Pejcic Snjezana

Introduction: Secondary failure (SF) to treatment with oral therapy is defined as the absence of a favorable reaction to the oral therapy which was effective in the previous course of the treatment. The aim of the work was to investigate the acute effects of the short-term insulin therapy on the secretory ability of endocrine pancreatic beta cells and the insulin resistance. Materials and Methods: 98 patients with diabetes mellitus type 2 (DM T2) and confirmed the SF to the or...

ea0022p135 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Insulin secretion and HOMA-IR in patients who underwent coronary angiography

Isailovic Tatjana , Petakov Milan , Ognjanovic Sanja , Macut DJuro , Popovic Bojana , Bozic Ivana , Elezovic Valentina , Damjanovic Svetozar

Introduction: Several population-based studies have shown that hyperinsulinemia and insulin resistance could be an independent predictive factor for development of coronary artery disease (CAD).Aim: The aim of this cross-sectional study was to analyze insulin secretion in patients with proven coronary artery disease.Methods: We have analyzed 151 consecutive patients (35–79 years old, men 68%, women 32%) referred for coronary a...

ea0022p169 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Bcl1 polymorphysm of glucocorticoid receptor gene in coronary artery disease

Popovic Bojana , Macut Djuro , Isailovic Tatjana , Bozic Ivana , Antic Jadranka , Ognjanovic Sanja , Petakov Milan , Damjanovic Svetozar

Introduction and aim: Obesity epidemic contributes to the increasing prevalence of high blood sugar, high blood pressure, and dyslipidemia, which are all known risk factors for coronary artery disease (CAD). Metabolic syndrome (MS) describes the common clinical finding wherein component CAD risk factors cluster within a single patient. Since obesity shares common clinical characteristics with both metabolic syndrome (MS) and Cushing’s syndrome it is speculated about obeso...

ea0022p243 | Clinical case reports and clinical practice | ECE2010

Nesidioblastosis in adult patient with neurofibromatosis type1 and synchronous multicentric duodenal somatostatinomas - case report

Ognjanovic Sanja , Petakov Milan , Macut Djuro , Isailovic Tatjana , Elezovic Valentina , Popovic Bojana , Bozic Ivana , Damjanovic Svetozar

Somatostatinomas are rare neuroendocrine tumors of the pancreas and small intestine that can occur sporadically or in a syndromic form. Duodenal somatostatinomas are often associated with neurofibromatosis type1 (NF1). Their presenting features are mostly related to local effects of the tumor mass rather than functional clinical syndrome. Nesidioblastosis is extremely rare cause of persistant hyperinsulinemic hypoglycaemia in adults.We present a case of ...