Searchable abstracts of presentations at key conferences in endocrinology

ea0063p33 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

Complete remission of a highly aggressive, metastasized, SDHB-related paraganglioma after chemotherapy with CVD and peptide-receptor radiotherapy

Meyer Gesine , Koch Christine , Bojunga Jorg

Case: A 40-year-old woman presented in 04/2015 with pain in the upper abdomen and a history of paroxysmal tachycardia. Plasma normetanephrines were highly elevated. Imaging revealed a large retroperitoneal tumor (15×12×8 cm), which could be completely resected after pre-treatment with urapidil. Histology confirmed diagnosis of a paraganglioma. Genetic diagnostics detected a previously unknown mutation in intron 2 of the SDHB-gene (c.200+5G>C). Six month after ini...

ea0063p94 | Calcium and Bone 1 | ECE2019

Osteitis Fibrosa Cystica – A Forgotten Clinical And Radiological Feature Of Primary Hyperparathyroidism

Katharina Flugel Anna , Mondorf Antonia , Bojunga Jorg

Introduction: Manifestations of primary hyperparathyroidism (PHPT) such as osteoporosis and stone diseases are common primary diagnostic findings beyond a hypercalcemia. Classical skeletal involvement can be the first sign of PHPT, but not recognized because osteitis fibrosa cystica (bone cysts, brown tumors of the long bones) is rarely seen today in Western Europe.Case report: A 34-year old women from Afghanistan was presented to our out-patient-clinic ...

ea0063p432 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Case report: giant adrenal myelolipoma in CAH – should all patients be screened by ultrasound for adrenal masses?

Mondorf Antonia , Flugel Anna Katharina , Meyer Gesine , Bojunga Jorg

Introduction: Myelolipomas account for 5–15% of all resected adrenal masses and are considered as benign lesions consisting of fat and myeloid tissue. Their pathogenesis is mostly unknown, though altered mesenchymal stem cell function or a sustained respond to increased ACTH stimulation are discussed. Even though these findings are partly inconclusive, an increased incidence of myelolipoma in patients with congenital adrenal hyperplasia (CAH) has been reported, which may ...

ea0041ep339 | Clinical case reports - Thyroid/Others | ECE2016

A rare case of sex reversal during puberty

Meyer Gesine , Sohn Michael , Badenhoop Klaus , Bojunga Jorg

A 34-year-old refugee from Somalia was referred because of a suspected DSD. Due to ambiguous, but predominantly female external genitalia at birth he was raised as a girl, whereas his subjective gender identity has always been male. Puberty led to a significant virilization of the body but only to a very limited virilization of the external genitalia. The patient presented himself with an undoubtedly male-type body composition. External genitalia were now predominantly male wi...

ea0016p155 | Clinical cases | ECE2008

Brown tumor of the mandible and osteitis fibrosa cystica in hyperparathyroidism: a rare disease mimicking an osseous metastasized malignancy

Waidmann Oliver , Grigorian Natalia , Zeuzem Stefan , Bojunga Jorg

Background: Osteolytic metastases of the bone occur in several malignant tumors. Beside osseous metastases, endocrine diseases like primary hyperparathyroidism can mimic osteolytic metastases.Case report: A 53-year-old woman was sent to the hospital by an oral surgeon with a worsening of her general condition, fatigue, a painful tumor of the mandible, diffuse bone pain and the diagnosis of a suspected metastasized malignancy. Laboratory testing showed a ...

ea0035p523 | Endocrine tumours and neoplasia | ECE2014

A rare case of an androgen-producing stromal luteoma of the ovary in a postmenopausal woman, diagnosed by means of selective venous blood sampling

Bogdanou Dimitra , Meyer Gesine , Stucker Anja-Undine , Hansmann Martin-Leo , Thalhammer Axel , Bojunga Jorg

Background: Multiple diagnostic modalities may be needed to establish the source of excessive androgen production in women. The detection of testosterone-producing ovarian tumors by imaging techniques can be difficult because of their in same cases small size and radiological structure.Case report: We describe a 55-year-old postmenopausal woman presenting with progressive severe virilization (Ferriman Gallwey-Score: 23–26), increased hair growth, ma...

ea0016s30.2 | Clinical highlights | ECE2008

Contrast-enhanced ultrasound of adrenal mass: differentiation between benign and malignant lesions

Friedrich-Rust Mireen , Schneider Guenther , Bohle Rainer M , Zeuzem Stefan , Bojunga Jorg

Background: Adrenal masses can be detected by ultrasound with high sensitivity and specificity. However, a differentiation between benign and malignant adrenal masses is presently not possible. Contrast-enhanced ultrasound has been studied intensively with excellent results for the characterization of liver lesions.The aim of the present study was to evaluate the value of contrast-enhanced ultrasound for the characterization of adrenal mass in a proof of...