Searchable abstracts of presentations at key conferences in endocrinology

ea0026s17.3 | Pituitary update | ECE2011

Pituitary late effects of radiotherapy for brain tumours

Bolanowski M

Radiotherapy of brain tumours given to children and adults is connected with various hormonal dysfunctions later in the life. There are anterior pituitary hormones deficiencies, hyperprolactinemia and precocious puberty. Their severity and frequency depends on the dose applied, age of the radiotherapy and time after radiotherapy. In children, the most important is early recognition of them, with growth hormone deficiency as most common. The impact of cranial irradiation on gon...

ea0029p1382 | Pituitary Clinical | ICEECE2012

Orexin A concentration is reduced in acromegaly, regardless activity of the disease

Jawiarczyk A. , Bolanowski M.

It has been reported that orexins play an important role in the regulation of GH secretion. It is suggested that the defect in orexins synthesis could be responsible for the disturbances in GH synthesis and consequently aggravate metabolic disturbances. The aim of the study was to assess plasma orexin A levels in patients with acromegaly in relation to the activity of disease and hormonal and metabolic profiles. Fifty-five patients with acromegaly divided into three groups acc...

ea0011p43 | Bone | ECE2006

Quantitative ultrasound at the hand phalanges in patients with acromegaly

Bolanowski M , Pluskiewicz W , Daroszewski J

Acromegaly is associated with various skeletal deformities and in some cases with bone deterioration. The aim of the study was to assess the skeletal status using quantitative ultrasound (QUS) in patients suffering from acromegaly. A group of 38 patients with acromegaly (27 women and 11 men) in mean age of 57.21±9.85 y in various gonadal status was compared with a control group matched for sex, age and body mass. QUS measurements at hand phalanges were performed with DBM ...

ea0011p402 | Diabetes, metabolism and cardiovascular | ECE2006

Flow mediated dilatation and svcam concentration as the markers of endothelial dysfunction in patients with acromegaly

Bolanowski M , Kaluzny M , Daroszewski J , Szuba A

Acromegaly causes various cardiovascular dysfunctions, and cardiovascular complications are the main cause of increased mortality in non-cured acromegalic patients. The aim of the study was assessment of flow mediated dilatation (FMD) and the concentration of soluble vascular cell adhesive molecule (sVCAM) as the selected markers of endothelial dysfunction in patients suffering from acromegaly. The study was carried out in 40 patients with acromegaly in various stages of the d...

ea0029p1590 | Thyroid (non-cancer) | ICEECE2012

Polymorphism of the PPAR-γ2 gene and Graves’ orbitopathy: the Ala variant confers decreased risk of eye symptoms

Daroszewski J. , Pawlak-Adamska E. , Bolanowski M. , Frydecka I.

Introduction: Peroxisome proliferatior-activated receptor-γ2 (PPAR-γ2) plays a crucial role in adipogenesis and has been shown to be involved in the control of immunoregulation and inflammation. Orbital fibroblast differentiation to adipocytes is a PPAR-γ dependent process essential for pathogenic tissue remodeling in Graves’ orbitopathy (GO). Genetic variation in PPAR-γ2 gene may modulate expression and/or function of molecule encoded by this gene.</p...

ea0026p389 | Thyroid (non cancer) | ECE2011

The CT60 and Jo31 polymorphisms of CTLA-4 gene are associated with disease progression in Graves’ disease

Daroszewski J , Pawlak-Adamska E , Bolanowski M , Frydecka I

Introduction: Both genetic and environmental factors contribute to clinical manifestation of Graves’ disease including the response to medical therapy. CTLA-4 gene is an important inhibitor of T-cell activation and its polymorphisms may influence the course of the disease.Goal: We investigated the association between CTLA−4 gene polymorphisms: c.49A>G, g.319C>T, g.*642AT(8_33), CT60, and Jo31 and the response to ph...