Searchable abstracts of presentations at key conferences in endocrinology

ea0011p764 | Steroids | ECE2006

Quantitative analysis of mifepristone (RU38486) in plasma by HPLC triple quadrupole mass spectrometry

Homer NZM , Small GR , Ooi LY , Bollina H , Reynolds RM , Walker BR , Andrew R

Mifepristone (RU38486) is a progesterone and glucocorticoid receptor antagonist which is used clinically to induce medical abortion, and as a research tool, e.g., in metabolic syndrome and depression. We aimed to develop a sensitive method to detect and quantify mifepristone in human plasma.Analyses were developed using a Surveyor HPLC system, with a mobile phase of methanol:ammonium acetate (5 mM) (70:30; 0.4 ml/min) and a C18 column (5 μm; 2.1&#21...