Searchable abstracts of presentations at key conferences in endocrinology

ea0015p294 | Reproduction | SFEBES2008

ERRα (NR3B1) expression in the human endometrium: functional consequences on the regulation of energy metabolism

Bombail Vincent , MacPherson Sheila , Critchley Hilary , Saunders Philippa

The oestrogen-receptor related orphan nuclear receptors (ERR) share significant sequence homology with oestrogen receptors (ER) alpha and beta but are unable to bind oestradiol. They are reported to constitutively regulate gene expression by binding to the ER response elements (ERE) or SF1 binding sites (SFRE) in gene promoters. However recent evidence from transgenic animal models point towards a role of these orphan nuclear receptors as regulators of energy-producing metabol...

ea0015oc9 | Reproduction | SFEBES2008

Dynamic responses of oestrogen receptors revealed by fluorescent recovery after photobleaching

Fitzgerald Carol , Collins Frances , Brown Pamela , Bombail Vincent , Kerr Karen , Macpherson Sheila , Millar Michael , Saunders Philippa

Oestrogen receptor (ER) activity has a wide spectrum of functions in the human body, including the development, growth and maintenance of the reproductive system. There are two ER subtypes, ERα and ERβ. The latter exists as multiple splice variants (ERβ1, ERβ2 and ERβ5) some of which lack a steroid ligand-binding domain. ERs act as steroid-ligand activated transcription factors. Epidermal growth factor (EGF) acting via the MAP kinase pathway has been s...

ea0013oc10 | Clinical and translational endocrinology | SFEBES2007

Expression of the orphan nuclear receptors oestrogen receptor related (ERR) alpha and beta in the human endometrium: implications for oestrogen receptor signalling

Bombail Vincent , MacPherson Sheila , Kerr Karen , McGarry Frances , Critchley Hilary , Saunders Philippa

Steroid receptors are members of a family of ligand-activated transcription factors that mediate tissue responses to a variety of endocrine stimuli. Using the human endometrium as a paradigm of a steroid responsive tissue, we aimed to characterise the expression and function of the oestrogen-receptor related orphan nuclear receptors (ERR) alpha and beta. ERRs share significant sequence homology with oestrogen receptors (ER) alpha and beta but are unable to bind oestradiol. The...