Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0081p602 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Mediterranean Diet and 12 months weight loss result in complex serum metabolomic and fecal metaproteomic changes in paediatric obesity

Spadaccini Daniele , Vita Vanella Virginia , Barberis Elettra , Ricotti Roberta , Bellone Simonetta , Bona Elisa , Antoniotti Valentina , Caputo Marina , Mancioppi Valentina , Rabbone Ivana , Manfredi Marcello , Prodam Flavia

Background: The relationship between composition and function of microbiota, obesity and nutrition has been increasingly studied and is still a challenge.Aims: To test whether in a group of 12 pediatric patients with obesity the treatment with a structured hospital and in-home Mediterranean Diet intervention had an impact on gut microbiota composition, function, and metabolite production, including Short chain fatty acids (SCFAs).M...
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ea0081p606 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The ecology of the microbiome in children with congenital generalized lipodystrophy type 4 (CGL4) is quickly modified after metreleptin treatment

Daffara Tommaso , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Massa Nadia , Caramaschi Alice , Mignone Flavio , Romanisio Martina , Rabbone Ivana , Giordano Mara , Aimaretti Gianluca , Bona Elisa , Prodam Flavia

Introduction: Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and genetic background. The role of microbiota is still uninvestigated.Objective: Evaluate the gut microbiome ecology in relation to dietary and clinical parameters in two infant siblings with congenital generalized lipodystrophy type 4 (CGL4) before and after treatment with recombinant leptin.Method...
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ea0090p608 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Intestinimonas butyriciproducens improves glucose metabolism in subjects with obesity and prediabetes: preliminary data from a randomized controlled trial

Antoniotti Valentina , Caputo Marina , TIni Sabrina , Antonioli Alessandro , Daffara Tommaso , De Marchi Silvia , Bona Elisa , Amoruso Angela , Pane Marco , Gul Sahin , Aimaretti Gianluca , Seegers Jos , Prodam Flavia

As the prevalence of type 2 Diabetes Mellitus (T2D) is constantly increasing and the current prevention is not enough, new effective strategies are necessary, in particular in high-risk individuals. Therapeutic microbiology is one of further proposed targets, and, in particular, butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyriciproducens as a preventive therapy for T2D in pre...
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ea0070aep373 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The educational training to the Mediterranean diet-like pattern is followed by improvement in cardiometabolic parameters and ecology of the microbiome in children with obesity: Preliminary results of the GOOD DAY trial

Ricotti Roberta , Archero Francesca , Landoni Valentina , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Solito Arianna , Novello Giorgia , Gamalero Elisa , Mignone Flavio , Cavaletto Maria , Agosti Emanuela , Bona Elisa , Prodam Flavia

Introduction: In the pediatric population the progression of obesity-related diseases can be delayed or prevented through changes in lifestyle, including the promotion of a Mediterranean-like dietary (MD) pattern.Objective: We aimed to assess the efficacy of an educational training to MD based on gamification with respect to a conventional weight-loss treatment in obese pediatric subjects on weight decreased and cardiometabolic risk factors (GOOD-DAY Tri...
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ea0073aep166 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The ecology of the microbiome in children with obesity is associated to insulin resistance anddiet composition

Ricotti Roberta , Archero Francesca , Landoni Valentina , Mancioppi Valentina , Caputo Marina , Bellone Simonetta , Solito Arianna , Antoniotti Valentina , Gamalero Elisa , Massa Nadia , Mignone Flavio , Cavaletto Maria , Agosti Emanuela , Bona Elisa , Prodam Flavia

IntroductionIn the pediatric population, the progression of obesity-related diseases can be delayed or prevented through lifestyle changes, including the promotion of a Mediterranean-like dietary (MD) pattern.ObjectiveWe aimed to evaluate the gut microbiome ecology in relation to dietary and clinical parameters in the pediatric subjects with obesity recruited at baseline in a protocol on an educational traini...
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ea0099oc12.2 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024

Intestinimonas butyriciproducens as a new preventive therapy for type 2 diabetes: a proof of concept randomized controlled trial

Antoniotti Valentina , Caputo Marina , Mollero Edoardo Luigi Maria , Antonioli Alessandro , TIni Sabrina , Manfredi Marcello , Bona Elisa , Pane Marco , Amoruso Angela , De Prisco Annachiara , Gul Sahin , Bui Nam , Seegers Jos , De Vos Willem M , Aimaretti Gianluca , Prodam Flavia

Background: The incidence of type 2 Diabetes Mellitus (T2D) is increasing worldwide. Prevention is possible by changing lifestyle but itÂ’s not effective alone in real life, due to poor compliance over time. New strategies are necessary, mostly for high-risk individuals. Therapeutic microbiology is a further proposed target, and butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyri...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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