Searchable abstracts of presentations at key conferences in endocrinology

ea0016p30 | Adrenal | ECE2008

Hormonal, metabolic and bone evaluation in a series of adrenal incidentalomas

Bonelli Lorenza , Giordano Roberta , Balbo Marcella , Berardelli Rita , Marinazzo Elisa , Ghigo Ezio , Arvat Emanuela

Clinically silent adrenal masses discovered by abdominal imaging procedures performed for non-adrenal disorders, i.e. adrenal incidentalomas, have become a common finding in clinical practice and they represent a clinical concern because of the risk not only of malignancy but also of subclinical hormonal hypersecretion (SCS) that represents a new risk factor for cardiovascular diseases and/or osteoporosis. We studied 73 patients (39F, 34M; mean±S.E.M.: 61.6...

ea0014p569 | (1) | ECE2007

Cortisol and dexamethasone exert different negative feedback action in humans

Giordano Roberta , Berardelli Rita , Picu Andreea , Balbo Marcella , Bonelli Lorenza , Barberis Anna , Ghigo Ezio , Arvat Emanuela

HPA response to glucocorticoids (GCs) feedback is usually tested by dexamethasone (DEX), a synthetic GC; it poorly crosses BBB and preferentially activates pituitaric glucocorticoid receptor (GR), with a binding potency to GR 7 fold higher and an anti-inflammatory potency about 35 fold higher than cortisol. Cortisol, which easily penetrates into CNS, could better evaluate the GC feedback by acting also at supra-pituitary level. We studied the effects of 150 min infusion of hyd...

ea0016p428 | Neuroendocrinology | ECE2008

Neuroendocrine effects of citalopram, a selective serotonin re-uptake inhibitor (SSRI), during lifespan in humans

Berardelli Rita , Margarito Enrica , Ghiggia Federica , Picu Andreea , Bonelli Lorenza , Balbo Marcella , Giordano Roberta , Bo Mario , Arvat Emanuela

Central serotoninergic activity (CSA) is known to influence the hypothalamus–pituitary–adrenal (HPA) axis, and a CSA loss seems to play a role in human brain aging and in etiology of functional hypercortisolism and depression, whose incidence increase with advancing age. Citalopram (CT), a SSRI, has been considered a good tool to evaluate CSA in humans. Aim of this study was to evaluate the neuroendocrine response to CT in healthy adult subjects during lifespan. We e...

ea0014p506 | (1) | ECE2007

Conventional glucocorticoid replacement therapy in patients with Addison’s disease: effects on metabolic and bone parameters

Balbo Marcella , Giordano Roberta , Bonelli Lorenza , Berardelli Rita , Picu Andreea , Benso Andrea , Bertagna Angela , Ghigo Ezio , Arvat Emanuela

In primary adrenal insufficiency hydrocortisone or cortisone are commonly used at doses of 30–37.5 mg/day as replacement therapy, though recent studies showed that cortisol normal production is about 5.7 mg/m2, equivalent to 20 mg/day of hydrocortisone, suggesting that supraphysiological doses are used. In 19 Addison’s disease patients (8 M, 11 F, 23–71 yr) under conventional glucocorticoid replacement therapy (37.5 mg cortisone/day) with low DHEAS le...

ea0014p622 | (1) | ECE2007

Ghrelin effects on spontaneous and stimulated LH secretion in human males

Bonelli Lorenza , Baldi Matteo , Broglio Fabio , Bertagna Angela , Di Bisceglie Cataldo , Tagliabue Milena , Manieri Chiara , Ghigo Ezio , Lanfranco Fabio

Acylated ghrelin (AG) participates in the modulation of the hypothalamic-pituitary-gonadal axis functions, with a predominantly inhibitory effect upon the reproductive system in animals. Animal studies have shown that ghrelin suppresses LH secretion in vivo, decreases LH responsiveness to GnRH in vitro and partially delays the timing of puberty in males. Aim of this study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secret...

ea0081rc4.5 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Validation of the ICD-codes for acromegaly – strategies to reduce false positive cases and improve estimation of the incidence in Sweden

Tsatsaris Erika , Robert Jonas , Berinder Katarina , Bonelli Lorenza , Burman Pia , Dahlqvist Per , Hoybye Charlotte , Ragnarsson Oskar , Vouzouneraki Konstantina , AEkerman Anna-Karin , Ekman Bertil , Eden Engstrom Britt

Purpose: We aimed to validate the diagnosis and estimated national incidence of acromegaly reported in the Swedish National Patient Register (NPR), based on clinically reported International Classification of Diseases (ICD-codes), in comparison with the Swedish Pituitary Register (SPR).Methods: All patients in NPR or SPR between 1991-2018 with the ICD-9 or ICD-10 diagnosis of acromegaly and age >18 years at diagnosis were included. The diagnosis was ...