ea0070aep37 | Adrenal and Cardiovascular Endocrinology | ECE2020
Whitaker Martin J
, Bonner Jennifer J
, Burt Howard
, Johnson Trevor N
, Porter John
, Ross Richard JM
Background: Replacing physiological cortisol levels is important for the long-term health of patients with adrenal insufficiency and congenital adrenal hyperplasia (CAH). Modified-release formulations of hydrocortisone are one strategy being used to replace the cortisol circadian rhythm in adult patients but there is no data in children. Physiologically based pharmacokinetic (PBPK) modelling is a valuable tool for paediatric drug development1; however, there are no ...