Searchable abstracts of presentations at key conferences in endocrinology

ea0077lb22 | Late Breaking | SFEBES2021

Effect of Enzalutamide on cortisol dynamics

Abouzaid Mona , Holliday Rachel , Boot Chris , Quinton Richard , Mamoojee Yaasir

Background: Enzalutamide is a next-generation androgen receptor (AR) antagonist, used as a daily oral agent, in the treatment of castration-resistant prostate cancer. Its suppression of 11β-hydroxysteroid dehydrogenase-2 enzyme has been reported in the literature, leading to hypertension through a relative increase in cortisol concentration at the level of the mineralocorticoid receptors. Enzalutamide is also known to be a potent inducer of drug metabolising enzymes (cyto...

ea0051p016 | Gonadal, DSD and reproduction | BSPED2017

Using salivary testosterone measurements to assess androgen deficiency in adults with Duchenne muscular dystrophy (DMD)

Sahun Yolanda Alins , Cheetham Tim , Boot Chris , Straub Vulker , Wood Claire

Background: Many adolescents and young adults with DMD receive long-term glucocorticoids (GC), a well-recognised cause of hypogonadotrophic hypogonadism. Pubertal induction is routinely offered to DMD adolescents in our centre but few individuals remain on supplementation into adulthood and it is unclear whether these men have age-appropriate endogenous testosterone production. Salivary testosterone (SalT) measurement is available but has not been used to assess androgen statu...