Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep664 | Pituitary and Neuroendocrinology | ECE2022

Peak cortisol level on synacthen stimulation test in cushing’s disease

Ali Rashid Razan , Boot Christopher S , James Andy , Mamoojee Yaasir

Background: Diagnostic work-up for Cushing ’s syndrome (CS) can be challenging, with variable performance characteristics on screening tests. We were recently referred a young female patient with Cushing’s disease (CD) due to a microadenoma. She presented with a seizure and initial biochemical work-up included a Synacthen stimulation test (SST). Her peak cortisol rose to over 1,000 nmol/l. Exaggerated response during SST is expected in hyperestrogenic states due to e...

ea0081rc2.3 | Rapid Communications 2: Adrenal and Cardiovascular Endocrinology 1 | ECE2022

Diagnostic accuracy of basal cortisol level to predict secondary adrenal insufficiency in patients with pituitary disease

Mathieson Campbell , Ali Rashid Razan , Boot Christopher S , James Andy , Mamoojee Yaasir

Objective: The 250 µg short Synacthen stimulation test (SST) is the most commonly used dynamic assessment to diagnose adrenal insufficiency (AI). There are challenges to the use of the SST in routine clinical practice, including staff and resource limitation in the current COVID-19 pandemic and Synacthen cost. We aimed to investigate the value of basal cortisol level for predicting AI in our selected cohort of patients at risk of secondary adrenal insufficiency from pitui...

ea0070oc6.6 | Hot Topics (including COVID-19 | ECE2020

Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalised with COVID-19 are associated with greater disease severity

Tee Su , Panagiotou Grigorios , Ihsan Yasir , Athar Waseem , Marchitelli Gabriella , Kelly Donna , Boot Christopher S , Stock Nadia , Macfarlane James , Martineau Adrian , Burns Graham , Quinton Richard

Background: The pandemic of Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is associated with higher fatality in respect of male sex, advancing age, obesity, diabetes, hypertension, climatic factors and, in the UK and North America, with darker-skinned ethnicities; in all of which circumstances vitamin D deficiency (VDD) is more common. 25(OH)D levels reach their nadir at the end of winter and have been associated wit...