Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep921 | Neuroendocrinology | ECE2017

Kallmann syndrome: about eleven clinical cases

Fonseca Liliana , Amaral Claudia , Dores Jorge , Palma Isabel , Carvalho Rui , Cardoso Helena , Vilaverde Joana , Borges Fatima

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

ea0049ep1279 | Thyroid (non-cancer) | ECE2017

Metastatic differentiated thyroid carcinoma: cumulative doses of adjunct 131i-iodide therapy

Gouveia Patricia , Pereira Teresa , Amado Ana , Teixeira Ricardo , Costa Antonio , Carvalho Andre , Freitas Claudia , Borges Fatima

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

ea0049ep1479 | Thyroid (non-cancer) | ECE2017

Incidence of thyroid cancer in the gray bethesda categories

Barbosa Berta , da Costa Moreira , Valente Vitor , Borges Fatima , Carvalho Andre

Objective: The recommendations for action in a Bethesda category III are to repeat the cytology or to perform molecular tests, and if these are inconclusive, surveillance or surgical indication may be maintained, depending on the risk factors, ultrasound characteristics of the nodule and patient preference. In case of category IV of Bethesda, the recommendation is the surgery. The objective of this study was to evaluate the impact of age, gender and nodule size on the incidenc...

ea0049ep1483 | Thyroid (non-cancer) | ECE2017

Is prophylactic central cervical dissection in papillary carcinoma of the thyroid justified?

Barbosa Berta , da Costa Moreira , Valente Vitor , Borges Fatima , Carvalho Andre

Objective: Thyroid cancer is the most common of the endocrine tumors, with papillary being the most frequent. There is no consensus about prophylactic central cervical dissection in patients with papillary carcinoma of the thyroid. The aim of this study is to analyze surgical complications and the rate of recurrence of papillary carcinoma in patients undergoing total thyroidectomy and prophylactic central cervical dissection, and patients submitted to total thyroidectomy alone...

ea0037ep865 | Thyroid cancer | ECE2015

Incidental papillary thyroid carcinoma prevalence in benign multinodular goitre: data from Northern Portugal

Pereira Maria Teresa , de Carvalho Andre Couto , Freitas Claudia , Borges Fatima

Introduction: Incidental papillary thyroid carcinoma (PTC) in patients undergoing thyroidectomy for benign multinodular disease is a well-recognised finding. Its true prevalence remains uncertain and shows great variability between studies, ranging from 7–25%. Our purpose was to review the prevalence of PTC in thyroid glands removed for benign nodular disease at a Northern Portuguese tertiary hospital.Methods: From December 2012 to December 2014, th...

ea0035p329 | Clinical case reports Thyroid/Others | ECE2014

Two serious complications of propylthiouracil treatment in the same patient: case report

Garrido Susana , Pereira Teresa , Marinho Antonio , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

ea0035p457 | Diabetes complications | ECE2014

Diabetic ketoacidosis and olanzapine: case report

Garrido Susana , Pereira Teresa , Freitas Claudia , Vilaverde Joana , Amaral Claudia , Carvalho Andre , Borges Fatima

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

ea0014p341 | (1) | ECE2007

Iodine intake in Portugal: preliminary results in pregnant women

Limbert Edward , Prazeres Susana , Miranda Ana , Castro João , Carrilho Francisco , Reguengo Henrique , Borges Fatima

Introduction: Iodine is the key element for the synthesis of thyroid hormones and its intake modulates the physiology and physiopathology of thyroid gland. In Portugal, endemic goiter has disappeared, but some data make us consider that iodine intake, as in other European areas, is far from being sufficient. Taking into account the potential harmful effects of moderate iodine deficiency during pregnancy, when needs are increased, and the absence of recent data on iodine intake...

ea0056p886 | Pituitary - Clinical | ECE2018

Acromegaly: surgical results and predictors for remission

Amado Ana , Figueiredo Goncalo , Ribeiro Isabel , Amaral Claudia , Borges Fatima , Cardoso Helena

Introduction: Acromegaly is a rare disease with significant morbidity and mortality. Surgical treatment is the first line treatment for these patients, with remission rates of >85% for microadenomas and 40–50% for macroadenomas.Objectives: Our objective was to characterize patients with acromegaly followed in our department and evaluate remission status after surgery. We also aimed to determine remission related factors.Me...

ea0049gp228 | Thyroid Cancer | ECE2017

Differentiated thyroid cancer – comparison between patients with and without remission

Amado Ana , Gouveia Patricia , Pereira Teresa Alves , Castro Rosa , da Costa Antonio Moreira , Carvalho Andre , Freitas Claudia , Borges Fatima

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...