Endocrine Abstracts

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

Introduction: 131I-iodide therapy (RIT) is an important treatment modality for patients with differentiated thyroid carcinoma (DTC). However, despite the overall excellent outcome, some DTC patients with poor prognosis may require multiple doses of radioactive iodine.Aim: The purpose of our study was to evaluate the efficacy of cumulative doses (CDs) of RIT in metastatic DTC patients.Material and methods: A retrospective study was ...

Objective: The recommendations for action in a Bethesda category III are to repeat the cytology or to perform molecular tests, and if these are inconclusive, surveillance or surgical indication may be maintained, depending on the risk factors, ultrasound characteristics of the nodule and patient preference. In case of category IV of Bethesda, the recommendation is the surgery. The objective of this study was to evaluate the impact of age, gender and nodule size on the incidenc...

Objective: Thyroid cancer is the most common of the endocrine tumors, with papillary being the most frequent. There is no consensus about prophylactic central cervical dissection in patients with papillary carcinoma of the thyroid. The aim of this study is to analyze surgical complications and the rate of recurrence of papillary carcinoma in patients undergoing total thyroidectomy and prophylactic central cervical dissection, and patients submitted to total thyroidectomy alone...

Introduction: Incidental papillary thyroid carcinoma (PTC) in patients undergoing thyroidectomy for benign multinodular disease is a well-recognised finding. Its true prevalence remains uncertain and shows great variability between studies, ranging from 7–25%. Our purpose was to review the prevalence of PTC in thyroid glands removed for benign nodular disease at a Northern Portuguese tertiary hospital.Methods: From December 2012 to December 2014, th...

Introduction: Thionamides are important drugs in the treatment of hyperthyroidism. Despite that, they can be associated with rare but serious complications, which require drug discontinuation.Case report: Sixty-five-year-old woman with Graves’ disease, treated in 2002 with methimazole and in remission until 2012. Recurrence of Graves’ disease was diagnosed in March 2012 and she was started on propylthiouracil (PTU) 150 mg per day. She presented...

Introduction: Patients with psychotic or depressive disorders have an increased risk of developing metabolic syndrome, not only because of their unhealthy lifestyle (sedentary habits, inadequate diet and smoking) but also because of the negative impact of antipsychotic agents (specially clozapine and olanzapine) on several metabolic features. These include overweight/obesity, dyslipidemia, development of new-onset type 2 diabetes, worsening of pre-existing diabetes and diabeti...

Introduction: Iodine is the key element for the synthesis of thyroid hormones and its intake modulates the physiology and physiopathology of thyroid gland. In Portugal, endemic goiter has disappeared, but some data make us consider that iodine intake, as in other European areas, is far from being sufficient. Taking into account the potential harmful effects of moderate iodine deficiency during pregnancy, when needs are increased, and the absence of recent data on iodine intake...

Introduction: Acromegaly is a rare disease with significant morbidity and mortality. Surgical treatment is the first line treatment for these patients, with remission rates of >85% for microadenomas and 40–50% for macroadenomas.Objectives: Our objective was to characterize patients with acromegaly followed in our department and evaluate remission status after surgery. We also aimed to determine remission related factors.Me...

Introduction: Differentiated thyroid cancer (DTC) is one of the most frequent forms of malignancy. Because of its favourable outcome and low mortality rates, identifying prognostic factors has been a challenge. Several risk stratification systems have been developed. Most of them include demographic and tumour specific features, as well as extrathyroidal extension. Our objective was to compare clinical characteristics between DTC patients with and without remission.<p clas...