Searchable abstracts of presentations at key conferences in endocrinology

ea0022p722 | Signal transduction | ECE2010

Peroxisome-proliferator-activated receptor gamma is required for modulating endothelial inflammatory response through a novel nongenomic mechanism

Cantini Giulia , Lombardi Adriana , Borgogni Elisa , Francalanci Michela , Ceni Elisabetta , Gelmini Stefania , Poli Giada , Galli Andrea , Serio Mario , Forti Gianni , Luconi Michaela

Besides their well-known anti-diabetic effects, the peroxisome proliferator-activated receptor γ (PPARγ) thiazolidinedione ligands (TZD) have been suggested to also display anti-inflammatory properties. The receptor role in mediating such effects is far from being elucidated. Here, we demonstrate that PPARγ is necessary for TZD to interfere with TNFα and IFNγ inflammatory activity in human endothelial cells. Different PPARγ ligands similarly inhib...